Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Barnes Alane P
 2. Date of Event Requiring Statement (Month/Day/Year)
07/26/2013		 3. Issuer Name and Ticker or Trading Symbol
BIOCRYST PHARMACEUTICALS INC [BCRX]
(Last)
(First)
(Middle)
1929 BRASSFIELD ROAD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, General Counsel & Corp Sec
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

RALEIGH, NC 27614		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 41,931
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Emp. Stock Option (Right to Buy) 09/18/2007(1) 09/18/2016 Common Stock 10,000 $ 9.95 D  
Emp. Stock Option (Right to Buy) 05/16/2008(1) 05/16/2017 Common Stock 3,512 $ 7.98 D  
Emp. Stock Option (Right to Buy) 03/14/2009(1) 03/14/2018 Common Stock 6,709 $ 3.26 D  
Emp. Stock Option (Right to Buy) 03/02/2010(1) 03/02/2019 Common Stock 13,500 $ 1.2 D  
Emp. Stock Option (Right to Buy) 03/01/2011(1) 03/01/2020 Common Stock 42,000 $ 6.68 D  
Emp. Stock Option (Right to Buy) 03/01/2012(2) 03/01/2021 Common Stock 30,000 $ 4.15 D  
Emp. Stock Option (Right to Buy) 03/01/2013(2) 03/01/2022 Common Stock 50,000 $ 4.73 D  
Emp. Stock Option (Right to Buy) 01/01/2014(3) 01/01/2023 Common Stock 100,000 $ 1.42 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Barnes Alane P
1929 BRASSFIELD ROAD
RALEIGH, NC 27614		       VP, General Counsel & Corp Sec  

Signatures

/s/ Alane P. Barnes 08/26/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Options become exercisable at the rate of 25% after 1 year and then 1/48 per month thereafter until fully vested and exercisable after 48 months.
(2) Options become exercisable at a rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant.
(3) 50,000 Annual Employee Stock Options become exercisable at the rate of 25% on each of the first, second, third and fourth anniversaries of the date of grant. 50,000 Retention Stock Options become exercisbale at the rate of 50% on each of the first and second anniversaries of the date of grant.

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