FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * DRAKEMAN DONALD L   2. Issuer Name and Ticker or Trading Symbol MEDAREX INC [MEDX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President & Chief Executive (Last) (First) (Middle) MEDAREX, INC., 707 STATE ROAD 3. Date of Earliest Transaction (Month/Day/Year) 09/06/2005 (Street) PRINCETON, NJ 08540 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, $.01 par value per share               244,537 D   Common Stock, $.01 par value per share               30,000 I by Spouse Common Stock, $.01 par value per share               43,072 I by Children Common Stock, $.01 par value per share               16,134 I by GRAT (1) Common Stock, $.01 par value per share               57,657 I by GRAT (2) Common Stock, $.01 par value per share               50,000 I By GRAT (10)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Options (Right to Buy)

$ 2.3125

06/06/1995

A

100,000

06/06/1996

06/05/2005

Common Stock

100,000

$ 0

100,000

D

Stock Options (Right to Buy)

$ 3.22

04/24/1996

A

40,000

08/24/1996

04/23/2006

Common Stock

40,000

$ 0

40,000

D

Stock Options (Right to Buy)

$ 3.43

11/01/1999

A

224,000

05/01/1999

10/31/2009

Common Stock

224,000

$ 0

224,000

D

Stock Options (Right to Buy)

$ 45.2

10/13/2000

A

43,788

04/13/2001

10/12/2010

Common Stock

43,788

$ 0

43,788

D

Stock Options (Right to Buy)

$ 45.2

10/13/2000

A

2,212

10/13/2001

10/12/2010

Common Stock

2,212

$ 0

2,212

D

Stock Options (Right to Buy)

$ 27.81

01/09/2001

A

116,405

07/09/2001

01/08/2011

Common Stock

116,405

$ 0

116,405

D

Stock Options (Right to Buy)

$ 27.81

01/09/2001

A

3,595

01/09/2002

01/08/2011

Common Stock

3,595

$ 0

3,595

D

Stock Options (Right to Buy)

$ 12.9

09/19/2001

A

400,000

09/19/2002(3)

09/18/2011

Common Stock

400,000

$ 0

400,000

D

Stock Options (Right to Buy)

$ 6.37

07/11/2002

A

300,000

07/11/2003(4)

07/10/2012

Common Stock

300,000

$ 0

300,000

D

Stock Options (Right to Buy)

$ 2.8

03/06/2003

A

107,000

03/06/2004(5)

03/05/2013

Common Stock

107,000

$ 0

107,000

D

Stock Options (Right to Buy)

$ 5.59

07/24/2003

A

14,000

01/24/2004

07/23/2013

Common Stock

14,000

$ 0

14,000

D

Stock Options (Right to Buy)

$ 7.155

10/14/2003

A

500,000

10/14/2004(7)

10/13/2013

Common Stock

500,000

$ 0

500,000

D

Stock Options (Right to Buy)

$ 0

08/08/1988(8)

08/08/1988(8)

Common Stock

0

278,000

I

by Spouse (6)

Stock Options (Right to Buy)

$ 5.61

07/26/2004

A

350,000

07/26/2005(9)

07/25/2014

Common Stock

350,000

$ 0

350,000

D

Stock Options (Right to Buy)

$ 9.9

09/06/2005

A

500,000

09/06/2006(11)

09/05/2015

Common Stock

500,000

$ 0

500,000

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
DRAKEMAN DONALD L MEDAREX, INC. 707 STATE ROAD PRINCETON, NJ 08540	X		President & Chief Executive

Signatures

Donald L. Drakeman		09/08/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These shares were previously reported as directly beneficially owned, but were contributed to a grantor retained annunity trust on December 30, 2002.
(2)	These shares were previously reported as directly beneficially owned, but were contributed to a grantor retained annuity trust on August 28, 2003.
(3)	Options representing 100,000 shares vested on September 19,2002. The remainig options vest in 36 equal monthly installments beginning on October 19,2002.
(4)	Options representing 75,000 shares vested on July 11, 2003. The remaining options vest in 36 equal monthly installments beginning on August 11, 2003.
(5)	Options representing 26,750 shares vested on March 6, 2004. The remaining options vest in 36 equal monthly installments beginning on April 6, 2004.
(6)	In addition to the options set forth above, Mr. Drakeman may be deemed to be the indirect beneficial owner of options covering an aggregate of 278,000 shares of Company common stock, which are owned by his wife. Mr. Drakeman disclaims beneficial ownership of all such securities.
(7)	Options representing 125,000 shares vested on October 14, 2004. The remaining options vest in 36 equal monthly installments beginning November 14, 2004.
(8)	In the Section 16 Electronic Reporting Frequently Asked Questions released by the SEC on May 1, 2003, the SEC has designated "08/08/1988" as a "dummy date" until the electronic system is modified. 08/08/1988 is not a transaction date related to these securities.
(9)	Options representing 87,500 shares vested on July 26, 2005. The remaining options vest in 36 equal monthly installments beginning August 26, 2005.
(10)	These shares were previously reported as directly beneficially owned, but were contributed to a grantor retained annuity trust on September 9, 2004.
(11)	Options representing 125,000 shares vest on September 6, 2006. The remaining options vest in 36 equal monthly installments beginning October 6, 2006.

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