Rule 425

Filed by Discovery Partners International, Inc. Pursuant to Rule 425

Under the Securities Act of 1933

and Deemed Filed Pursuant to Rule 14a-12

Under the Securities Exchange Act of 1934

Subject Company: Infinity Pharmaceuticals Inc.

Commission File No. 333-134438

On August 9, 2006, Discovery Partners International, Inc. (the “Company”) issued a press release announcing, among other things, its financial results for the three and six month periods ended June 30, 2006. The text of the press release is as follows:

LOGO

 

Company Contact:   
Discovery Partners International   
Acting Chief Executive Officer   

Chief Financial Officer

Michael C. Venuti, Ph.D.   

Craig Kussman

858-455-8600   

(858) 228-4113

ir@discoverypartners.com   

FOR IMMEDIATE RELEASE

DISCOVERY PARTNERS INTERNATIONAL REPORTS SECOND QUARTER 2006 RESULTS

San Diego, CA –August 9, 2006 – Discovery Partners International, Inc. (NASDAQ: DPII) today announced unaudited financial results for the three and six month periods ended June 30, 2006.

Following the Company’s sale of all of the stock of its operating subsidiaries and all of its material operating assets pursuant to a stock and asset purchase agreement with Galapagos NV and Biofocus Inc., a subsidiary of Galapagos NV, and the sale of the instrumentation product lines in 2005, the Company no longer reports any revenue nor associated expense, nor any historical operating results related to its operating activities. These results are reported as discontinued operations. The Company’s results from continuing operations arise solely from general and administrative and other expenses related to its corporate activities and investment income on its marketable securities portfolio.

Net loss from continuing operations for the three months ended June 30, 2006 was $3.2 million, or $0.12 per share, compared to a net loss of $2.2 million, or $0.08 per share, for the same period in 2005. Net loss from continuing operations for the six months ended June 30, 2006 was $5.3 million, or $0.20 per share, compared to a net loss of $4.9 million, or $0.19 per share, for the same period in 2005.


Selling, general and administrative costs for the second quarter of 2006 were $4.1 million, up from $2.6 million in the second quarter of 2005 due to costs related to the Company’s strategic initiatives, which more than offset savings from lower staffing levels. Selling, general and administrative costs for the first half of 2006 were $7.0 million, up from $5.7 million in the first half of 2005 due to costs related to the Company’s strategic initiatives, which more than offset the absence of severance payments to our former COO and savings from lower staffing levels.

Investment income for the three and six months ended June 30, 2006 were $0.9 million and $1.8 million, respectively, up from $0.4 million and $0.9 million, respectively, for the same periods in 2005 due to higher yields on the Company’s investment portfolio.

Net loss from discontinued operations for the three months ended June 30, 2006 was $1.2 million, or $0.05 per share, compared to net income of $0.8 million, or $0.03 per share, for the same period in 2005. Net loss from discontinued operations for the six months ended June 30, 2006 was $8.3 million, or $0.31 per share, compared to a net loss of $1.0 million, or $0.04 per share, for the same period in 2005. The increased loss for both periods resulted primarily from a significant reduction in revenue generated from the discontinued operations in 2006 versus 2005.

Cash, cash equivalents and short-term investments at June 30, 2006 were $75.4 million, a decrease of $4.7 million from the balance at March 31, 2006 due primarily to the net loss. This cash number does not reflect the $5.4 million received from the sale of our operational assets to Galapagos NV in early July.

“During the second quarter of 2006, Discovery Partners announced both the merger with Infinity Pharmaceuticals, and the sale of our drug discovery business to Galapagos NV for $5.4 million in cash,” said Michael C. Venuti, Ph.D., Acting Chief Executive Officer of Discovery Partners. “Importantly, we were able to complete the sale to Galapagos NV without incurring either major severance or shutdown costs. The combination of these strategic initiatives is intended to afford our shareholders the opportunity to participate in the growth associated with the cancer drug development portfolio of Infinity. The date for the special meeting Discovery Partners’ shareholders to vote on the Infinity merger and related matters is September 12, 2006,” concluded Venuti.

About Discovery Partners International, Inc.

Discovery Partners International, Inc. (DPI) has entered into a merger agreement with Infinity pursuant to which Infinity will merge with and into a wholly owned subsidiary of Discovery Partners, with Infinity as the surviving corporation, becoming a wholly owned subsidiary of Discovery Partners. In connection with the merger, Discovery Partners recently completed the sale of all of the stock of its operating subsidiaries and all of its material operating assets pursuant to a stock and asset purchase agreement with Galapagos NV. and Biofocus Inc., a subsidiary of Galapagos NV. Discovery Partners’ only remaining material assets following that sale are its cash, cash equivalents and short-term investments, its listing on the NASDAQ Global Market and its merger agreement with Infinity. The terms of the Infinity merger agreement and the stock and asset purchase agreement with Galapagos and Biofocus, and the remaining assets of Discovery Partners following the closing of the transactions described in such agreements are contained in Discovery Partners’ filings with the Securities and Exchange Commission and are available on the Company’s web site at http://www.discoverypartners.com.


About Infinity Pharmaceuticals, Inc.

Infinity is an innovative cancer drug discovery and development company that leverages its strength in small molecule technologies to bring important new medicines to patients. For more information on Infinity Pharmaceuticals, including a copy of this release in the Media Room, please visit the company’s web site at http://www.ipi.com.

Additional Information about the Merger and Where to Find It

In connection with the proposed merger transaction with Infinity, on August 7, 2006 an amended registration statement was filed with and has been declared effective by the Securities and Exchange Commission that contains a proxy statement/prospectus. Investors and security holders of Discovery Partners and Infinity are urged to read the proxy statement/prospectus (including any amendments or supplements to the proxy statement/prospectus) regarding the proposed transaction because it contains important information about Discovery Partners, Infinity and the proposed transaction. Discovery Partners’s stockholders can obtain a free copy of the proxy statement/prospectus, as well as other filings containing information about Discovery Partners and Infinity, without charge, at the SEC’s Internet site (http://www.sec.gov). Copies of the proxy statement/prospectus can also be obtained, without charge, by directing a request to Discovery Partners International, Inc., 9640 Towne Centre Drive, San Diego, CA 92121, Attention: Investor Relations, Telephone: (858) 455-8600.

Participants in the Solicitation

Discovery Partners and its directors and executive officers and Infinity and its directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of Discovery Partners in connection with the proposed transaction. Information regarding the special interests of these directors and executive officers in the merger transaction is included in the proxy statement/prospectus referred to above. Additional information regarding the directors and executive officers of Discovery Partners is also included in Discovery Partners’s proxy statement for its 2006 Annual Meeting of Stockholders, which was filed with the SEC on April 6, 2006. This document is available free of charge at the SEC’s web site (http://www.sec.gov) and from Discovery Partners’s Investor Relations at the address listed above.

Forward-Looking Statements

This release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding the proposed transaction and, the growth associated with Infinity’s drug portfolio. Factors that may cause actual results to differ materially include the risk that Discovery Partners and Infinity may not be able to complete the proposed transaction, the risk that Infinity product candidates that appeared promising in early research and clinical trials do not demonstrate safety and/or efficacy in larger-scale or later clinical trials, the risk that Infinity will not obtain approval to market its products, the risks associated with reliance on outside financing to meet capital requirements, and the risks associated with reliance on collaborative partners for further clinical trials, development and commercialization of product candidates. You are urged to consider statements that include the words “may,” “will,” “would,” “could,” “should,” “believes,” “estimates,” “projects,” “potential,” “expects,” “plans,” “anticipates,” “intends,” “continues,” “forecast,” “designed,” “goal,” or the negative of those words or other comparable words to be uncertain and forward-looking. These factors and others are more fully discussed in Discovery Partners’s periodic reports and other filings with the SEC.


Any forward-looking statements are made pursuant to Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and, as such, speak only as of the date made. Discovery Partners undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.


DISCOVERY PARTNERS INTERNATIONAL, INC.

Selected Consolidated Financial Data

(In Thousands, Except Per Share Amounts)

Consolidated Statements of Operations

 

    

Three Months Ended

June 30

   

Six Months Ended

June 30

 
     2006     2005     2006     2005  
     (Unaudited)     (Unaudited)  

Operating expenses:

        

Selling, general and administrative

     4,124       2,619       7,000       5,742  

Restructuring

     —         —         22       —    
                                

Total operating expenses

     4,124       2,619       7,022       5,742  
                                

Loss from continuing operations

     (4,124 )     (2,619 )     (7,022 )     (5,742 )

Interest income, net

     896       413       1,752       878  

Foreign currency transaction gain (loss), net

     —         —         (11 )     (4 )

Other income, net

     (9 )     (3 )     4       —    
                                

Loss from continuing operations before income taxes

     (3,237 )     (2,209 )     (5,277 )     (4,868 )

Income tax refund

     —         (11 )     —         —    
                                

Net loss from continuing operations

   $ (3,237 )   $ (2,198 )   $ (5,277 )   $ (4,868 )
                                

Discontinued operations:

        

Gain on sale of discontinued operations

     —         —         165       —    

Income (loss) from discontinued operations

     (1,177 )     830       (8,341 )     (1,048 )
                                

Net loss

   $ (4,414 )   $ (1,368 )   $ (13,453 )   $ (5,916 )
                                

Basic and diluted:

        

Continuing operations

   $ (0.12 )   $ (0.08 )   $ (0.20 )   $ (0.19 )
                                

Discontinued operations

   $ (0.05 )   $ 0.03     $ (0.31 )   $ (0.04 )
                                

Net loss per share

   $ (0.17 )   $ (0.05 )   $ (0.51 )   $ (0.23 )
                                

Weighted average shares outstanding:

        

Basic and diluted:

     26,116       25,853       26,114       25,848  
                                


Summary Balance Sheets

(In Thousands)

 

    

June 30,

2006

   

December 31,

2005

 
     (Unaudited)        

Assets

    

Current assets:

    

Cash and cash equivalents

   $ 25,652     $ 24,231  

Short-term investments, net

     49,783       59,255  

Prepaid and other current assets

     1,715       1,050  

Assets of discontinued operations

     10,541       16,618  
                

Total current assets

     87,691       101,154  

Restricted cash

     —         1,061  

Other assets, net

     —         64  
                

Total assets

   $ 87,691     $ 102,279  
                

Liabilities and Stockholders’ Equity

    

Current liabilities:

    

Accounts payable and accrued expenses

   $ 568     $ 742  

Accrued compensation

     495       421  

Liabilities of discontinued operations

     4,042       6,042  
                

Total current liabilities

     5,105       7,205  

Stockholders’ Equity:

    

Common stock

     26       26  

Common stock issuable

     —         1,597  

Treasury stock

     (1,037 )     (1,037 )

Additional paid-in-capital

     210,690       209,237  

Deferred compensation

     —         (919 )

Accumulated other comprehensive income

     253       64  

Accumulated deficit

     (127,346 )     (113,893 )
                

Total stockholders’ equity

     82,586       95,075  
                

Total liabilities and stockholders’ equity

   $ 87,691     $ 102,279  
                


Summary Statement of Cash Flows

(In Thousands)

 

    

Six Months Ended

June 30, 2006

 
     (Unaudited)  

Net Loss

   $ (13,453 )

Adjustments to reconcile net loss to cash and cash equivalents used in operating activities:

  

Gain on sale of discontinued operations

     (165 )

Depreciation and amortization

     (27 )

Stock based compensation

     751  

Restructuring expense

     22  

Realized loss on investments

     (4 )

Change in operating assets and liabilities:

  

Other current assets

     515  

Accounts payable and accrued expenses

     (168 )
        

Net cash used in operating activities

     (12,529 )

Net cash provided by operating activities of discontinued operations

     5,519  

Investing activities:

  

Proceeds from sale of division

     165  

Proceeds from sales and maturity of short-term investments, net of purchases

     9,498  
        

Net cash provided by investing activities

     9,663  

Net cash used in investing activities of discontinued operations

     (1,372 )

Financing activities:

  

Net proceeds from issuance of common stock

     24  
        

Net cash provided by financing activities

     24  

Effect of exchange rate changes

     116  
        

Net increase in cash and cash equivalents

     1,421  

Cash and cash equivalents at beginning of period

     24,231  
        

Cash and cash equivalents at end of period

   $ 25,652