UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F COVER PAGE Report for the Calendar Year or Quarter Ended: September 30, 2005 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name:GENERAL AMERICAN INVESTORS COMPANY, INC. Address: 450 Lexington Ave, Suite 3300 New York, NY 10017 13F File Number: 28-461 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Eugene S. Stark Title: Vice-President, Administration Phone: 212-916-8447 Signature, Place, and Date of Signing: Eugene S. Stark New York, NY November 1, 2005 Report Type (Check only one.): [X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. List of Other Managers Reporting for this Manager: Form 13F File Number Name I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 59 Form 13F Information Table Value Total: $1282288499 List of Other Included Managers: No. 13F File Number Name VALUE SHARES/ SH/ PUT/ INVSTMT -----VOTING AUTHORITY----- NAME OF ISSUER -TITLE OF CLASS- --CUSIP-- x$1000 PRN AMT PRN CALL DSCRETN -MANAGERS- SOLE SHARED NONE Arch Capital Group Ltd. COMMON G0450A105 17357 350000 SH SOLE 350000 0 0 Adams Express Company COMMON 006212104 1306 99518 SH SOLE 99518 0 0 American International Group,Inc COMMON 026874107 21686 350000 SH SOLE 350000 0 0 Alkermes, Inc. COMMON 01642T108 4452 265000 SH SOLE 265000 0 0 The Allstate Corporation COMMON 020002101 6911 125000 SH SOLE 125000 0 0 American Tower Corporation COMMON 029912201 16841 675000 SH SOLE 675000 0 0 Annuity and Life Re (Holdings), COMMON G03910109 560 500000 SH SOLE 500000 0 0 Apache Corporation COMMON 037411105 50021 665000 SH SOLE 665000 0 0 Bank of America Corporation COMMON 060505104 13262 315000 SH SOLE 315000 0 0 Bancroft Convertible Fund COMMON 059695106 385 21088 SH SOLE 21088 0 0 Biogen Idec Inc. COMMON 09062X103 7106 180000 SH SOLE 180000 0 0 Berkshire Hathaway Inc. Class A COMMON 084670108 24600 300 SH SOLE 300 0 0 Brooks Automation, Inc. COMMON 114340102 6552 491500 SH SOLE 491500 0 0 Central Securities Corporation COMMON 155123102 3026 119319 SH SOLE 119319 0 0 CIENA Corporation COMMON 171779101 1452 550000 SH SOLE 550000 0 0 Costco Wholesale Corporation COMMON 22160K105 30163 700000 SH SOLE 700000 0 0 Cisco Systems, Inc. COMMON 17275R102 16128 900000 SH SOLE 900000 0 0 CEMEX, S.A. de C.V. ADR COMMON 151290889 59781 1143041 SH SOLE 1143041 0 0 Cytokinetics, Incorporated COMMON 23282W100 4477 550000 SH SOLE 550000 0 0 Diageo plc COMMON 25243Q205 20304 350000 SH SOLE 350000 0 0 Dollar General Corporation COMMON 256669102 13755 750000 SH SOLE 750000 0 0 Genentech, Inc. COMMON 368710406 30737 365000 SH SOLE 365000 0 0 Devon Energy Corporation COMMON 25179M103 91978 1340000 SH SOLE 1340000 0 0 EMC Corporation COMMON 268648102 3882 300000 SH SOLE 300000 0 0 EMCORE Corporation COMMON 290846104 1206 197000 SH SOLE 197000 0 0 EOG Resources, Inc. COMMON 26875P101 44940 600000 SH SOLE 600000 0 0 Ethan Allen Interiors Inc. COMMON 297602104 8621 275000 SH SOLE 275000 0 0 Golden West Financial COMMON 381317106 34743 585000 SH SOLE 585000 0 0 Halliburton Company COMMON 406216101 30149 440000 SH SOLE 440000 0 0 The Home Depot, Inc. COMMON 437076102 73229 1920000 SH SOLE 1920000 0 0 Lafarge North America Inc. COMMON 505862102 11832 175000 SH SOLE 175000 0 0 Lamar Advertising Company COMMON 512815101 15873 350000 SH SOLE 350000 0 0 Medtronic, Inc. COMMON 585055106 24129 450000 SH SOLE 450000 0 0 MedImmune, Inc. COMMON 584699102 13460 400000 SH SOLE 400000 0 0 MetLife, Inc. COMMON 59156R108 14202 285000 SH SOLE 285000 0 0 MFA Mortgage Investments, Inc. COMMON 55272X102 5670 925000 SH SOLE 925000 0 0 Millennium Pharmaceuticals, Inc. COMMON 599902103 1120 120000 SH SOLE 120000 0 0 Molex Incorporated Class A COMMON 608554200 14141 550000 SH SOLE 550000 0 0 Microsoft Corporation COMMON 594918104 39238 1525000 SH SOLE 1525000 0 0 M&T Bank Corporation COMMON 55261F104 32770 310000 SH SOLE 310000 0 0 North Fork Bancorporation, Inc. COMMON 659424105 14025 550000 SH SOLE 550000 0 0 Annaly Mortgage Management, Inc. COMMON 035710409 8741 675000 SH SOLE 675000 0 0 PepsiCo, Inc. COMMON 713448108 9924 175000 SH SOLE 175000 0 0 Pfizer Inc COMMON 717081103 32461 1300000 SH SOLE 1300000 0 0 PartnerRe Ltd. COMMON G6852T105 25620 400000 SH SOLE 400000 0 0 Patterson-UTI Energy, Inc. COMMON 703481101 27060 750000 SH SOLE 750000 0 0 Everest Re Group, Ltd. COMMON G3223R108 53845 550000 SH SOLE 550000 0 0 Reinsurance Group of America, COMMON 759351109 8940 200000 SH SOLE 200000 0 0 Republic Services, Inc. COMMON 760759100 41466 1175000 SH SOLE 1175000 0 0 Royce Value Trust COMMON 780910105 2192 110259 SH SOLE 110259 0 0 SunTrust Banks, Inc. COMMON 867914103 13890 200000 SH SOLE 200000 0 0 The TJX Companies, Inc. COMMON 872540109 51200 2500000 SH SOLE 2500000 0 0 Talisman Energy Inc. COMMON 87425E103 38647 791300 SH SOLE 791300 0 0 Total S.A. ADR COMMON 89151E109 44821 330000 SH SOLE 330000 0 0 Transatlantic Holdings, Inc. COMMON 893521104 14250 250000 SH SOLE 250000 0 0 VeriSign, Inc. COMMON 92343E102 2853 133500 SH SOLE 133500 0 0 Weatherford International Ltd. COMMON G95089101 29181 425000 SH SOLE 425000 0 0 Wal-Mart Stores, Inc. COMMON 931142103 25197 575000 SH SOLE 575000 0 0 Xerox Corporation COMMON 984121103 25935 1900000 SH SOLE 1900000 0 0