UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                     September 15, 2004 (September 9, 2004)

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
               (state or other juris- (Commission (I.R.S. Employer
           diction of incorporation) File Number) (Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080


          (Former name or former address, if changed since last report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12) [ ] Pre-commencement  communications pursuant to Rule 14d-2(b) under
the Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))








Section 1 - Registrant's Business and Operations

Item 1.01 Entry into a Material Definitive Agreement.

On September  9, 2004,  our board of  directors,  at the  recommendation  of the
Compensation  Committee,  approved an amended and restated employment  agreement
and an engagement  agreement  with Dr.  William A. Carter.  These two agreements
primarily  reflect  a  clarification  and  separation  of Dr.  Carter's  exiting
responsibilities,  with compensation in the aggregate equal to that contained in
the old employment  agreement and in our arrangement  with Dr. Carter since 1998
to pay him the fees previously paid to him by Hahnemann Medical University.

The  amended  and  restated  employment  agreement  provides  for  Dr.  Carter's
employment as our Chief Executive Officer and Chief Scientific Officer until May
8,  2008  unless  sooner  terminated  for  cause or  disability.  The  agreement
automatically   renews  for  successive  one  year  periods  after  the  initial
termination  date unless we or Dr. Carter give written notice otherwise at least
ninety days prior to the termination date or any renewal period.  Dr. Carter has
the right to terminate  the  agreement  on 30 days' prior  written  notice.  The
initial  base  salary  retroactive  to January 1, 2004 is  $282,415,  subject to
adjustment based on the average increase or decrease in the Consumer Price Index
for the prior year. In addition,  Dr. Carter could receive an annual performance
bonus  of up to  25%  of  his  base  salary,  at  the  sole  discretion  of  the
Compensation  Committee of the board of directors,  based on his  performance or
our  operating  results.  Dr.  Carter will not  participate  in any  discussions
concerning the determination of his annual bonus. Dr. Carter is also entitled to
an incentive  bonus of 0.5% of the gross proceeds  received by us from any joint
venture  or  corporate  partnering  arrangement,  up  to  an  aggregate  maximum
incentive bonus of $250,000 for all such  transactions.  Dr. Carter's  agreement
also provides that he be paid a base salary and benefits through the last day of
the then term of the agreement if he is terminated without "cause", as that term
is defined in the agreement.  Pursuant to his original agreement, Dr. Carter was
granted options to purchase 73,728 (post split) shares in 1991.

The  engagement  agreement,  retroactive  to January 1, 2004,  provides  for our
engagement of Dr. Carter as a consultant related to patent  development,  as one
of our  directors  and as chairman of the  Executive  Committee  of our board of
directors  until May 8, 2008 unless sooner  terminated  for cause or disability.
The agreement  automatically  renews for  successive  one year periods after the
initial  termination  date unless we or Dr. Carter give written notice otherwise
at least ninety days prior to the termination  date or any renewal  period.  Dr.
Carter  has the right to  terminate  the  agreement  on 30 days'  prior  written
notice.  The  initial  base fee as of  January 1, 2004 is  $201,725,  subject to
annual adjustments equal to the percentage increase or decrease of annual dollar
value of directors'  fees provided to our directors  during the prior year.  The
annual fee is further  subject to  adjustment  based on the average  increase or
decrease in the Consumer Price Index for the prior year. In addition, Dr. Carter
could receive an annual  performance  bonus of up to 25% of his base fee, at the
sole discretion of the Compensation  Committee of the board of directors,  based
on  his  performance.  Dr.  Carter  will  not  participate  in  any  discussions
concerning the  determination of this annual bonus. Dr. Carter's  agreement also
provides  that he be paid his base fee  through the last day of the then term of
the agreement if he is terminated  without  "cause",  as that term is defined in
the agreement.




Section 9 - Financial Statements and Exhibits

Item 9.01 Financial Statements and Exhibits.

10.1     Amended and Restated Employment Agreement of Dr. William A. Carter.
10.2     Engagement Agreement with Dr. William A. Carter.











                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                 HEMISPHERX BIOPHARMA, INC.


September 15, 2004         By: /s/Ransom W. Etheridge
                                                 --------------------------
                                                 Ransom W. Etheridge, Secretary