SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                         March 15, 2004 (March 15, 2004)

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)



            Delaware                    0-27072         52-0845822
           (state or other juris-     (Commission     (I.R.S. Employer
          diction of incorporation)    File Number)   (Identification No.)


              1617 JFK Boulevard, Philadelphia, Pennsylvania    19103
               (Address of principal executive offices)      (Zip Code)


       Registrant's telephone number, including area code: (215) 988-0080

          ------------------------------------------------------------
          (Former name or former address, if changed since last report)





ITEM 7.           Financial Statements And Exhibits.

            (c) Exhibits. The following exhibits are filed herewith:

                    The following exhibit is filed herewith:

Exhibit No.                                 Exhibit Title

99.1                       Press Release, dated March 15, 2004 issued by us*

-------------------------------

* This information shall not be deemed "filed" for purposes of Section 18 of the
Securities  Exchange  Act of 1934,  and  shall  not be  deemed  incorporated  by
reference in any filing with the  Securities and Exchange  Commission  under the
Securities  Exchange  Act of 1934 or the  Securities  Act of 1933,  whether made
before or after the date hereof and  irrespective  of any general  incorporation
language in any filings.


ITEM 12.          Results of Operations and Financial Condition.


On March 15,  2004,  we issued a press  release  announcing  our results for the
fiscal year ended  December 31, 2003. A copy of the press release is attached as
Exhibit 99.1 to this report.

The information  contained in this report and exhibit  attached hereto are being
furnished  pursuant  to Item 12 of Form 8-K and shall not be deemed  "filed" for
purposes of Section 18 of the Securities Exchange Act of 1934, nor shall they be
deemed  incorporated by reference in any filing with the Securities and Exchange
Commission  under the  Securities  Exchange Act of 1934 or the Securities Act of
1933,  whether  made  before or after the date  hereof and  irrespective  of any
general incorporation language in any filings.






                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            HEMISPHERX BIOPHARMA, INC.


March 15, 2004                              By:  /s/ William A Carter
                                            --------------------------------
                                            William A. Carter, M.D., President