SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934
Filed by the  Registrant  [ X ]
Filed by a Party other than the  Registrant  [ ]
Check the appropriate box:
[X  ]    Preliminary Proxy Statement
[ ]  Confidential,  for  Use  of the  Commission  Only  (as  Permitted  by  Rule
14a-6(e)(2)) [ ] Definitive Proxy Statement [ ] Definitive  Additional Materials
[ ] Solicitation  Material  Pursuant to Rule 14a-11(c) or rule 14a-12
                           Hemispherx Biopharma, Inc.
               ----------------------------------------------------
                (Name of Registrant as Specified in its Charter)
17:
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):

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[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

1)  Title of each class of securities to which transaction applies:
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2)  Aggregate number of securities to which transaction applies:
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    computed  pursuant  to  Exchange  Act Rule 0-11 (Set forth the
    amount on which the filing fee is calculated  and state how it
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5)  Total fee paid:
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[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as  provided  by  Exchange
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         (1)      Amount Previously Paid:
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         (4)      Date Filed:


 2
                           HEMISPHERX BIOPHARMA, INC.
                               1617 JFK Boulevard
                        Philadelphia, Pennsylvania 19103

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JUNE 23, 2004

To the Stockholders of Hemispherx Biopharma, Inc.:

         You are cordially  invited to attend the Annual Meeting of Stockholders
of Hemispherx Biopharma, Inc. ("Hemispherx"), a Delaware corporation, to be held
at the Embassy Suites, 1776 Benjamin Franklin Parkway, Philadelphia Pennsylvania
19103, on Wednesday,  June 23, 2004, at 10:00 a.m. local time, for the following
purposes:

     1. To elect six members to the Board of  Directors of  Hemispherx  to serve
until their respective successors are elected and qualified;

     2. To ratify the selection by Hemispherx's  audit committee of BDO Seidman,
LLP,  independent  public  accountants,  to audit the  financial  statements  of
Hemispherx for the year ending December 31, 2004;

     3. To approve  the  issuance of our common  stock upon  exercise of certain
warrants and conversion of certain  debentures to comply with AMEX Company Guide
Section 713;

     4. To adopt the Hemispherx 2004 Equity Incentive Plan; and

     5. To transact  such other  matters as may properly come before the meeting
or any adjournment thereof.

     Only  stockholders of record at the close of business on April 26, 2004 are
entitled to notice of and to vote at the meeting.

     A proxy  statement and proxy are enclosed.  If you are unable to attend the
meeting in person you are urged to sign,  date and  return  the  enclosed  proxy
promptly in the self  addressed  stamped  envelope  provided.  If you attend the
meeting in person,  you may withdraw  your proxy and vote your  shares.  We have
also enclosed our annual report on Form 10-K for the fiscal year ended  December
31, 2003.

                                               By Order of the Board
                                               of Directors

                                               s\Ransom W. Etheridge, Secretary

Philadelphia, Pennsylvania
May   , 2004







                                 PROXY STATEMENT


                           HEMISPHERX BIOPHARMA, INC.
                               1617 JFK Boulevard
                        Philadelphia, Pennsylvania 19103


                                  INTRODUCTION


         This proxy statement is furnished in connection  with the  solicitation
of  proxies  for  use  at the  annual  meeting  of  stockholders  of  Hemispherx
Biopharma,  Inc.  ("Hemispherx" or the "Company") to be held on Wednesday,  June
23, 2004, and at any  adjournments.  The accompanying  proxy is solicited by the
Board  of  Directors  of  Hemispherx  and is  revocable  by the  stockholder  by
notifying Hemispherx's Corporate Secretary at any time before it is voted, or by
voting in person at the annual meeting.  This proxy  statement and  accompanying
proxy will be  distributed to  stockholders  beginning on or about May 17, 2004.
The principal executive offices of Hemispherx are located at 1617 JFK Boulevard,
Philadelphia, Pennsylvania 19103, telephone (215) 988-0080.


                      OUTSTANDING SHARES AND VOTING RIGHTS

RECORD DATE; OUTSTANDING SHARES

         Only stockholders of record at the close of business on April 26, 2004,
the record  date,  are  entitled  to  receive  notice of, and vote at the annual
meeting.  As of the record date, the number and class of stock  outstanding  and
entitled to vote at the meeting was 42,363,928 shares of common stock, par value
$.001 per  share.  Each  share of common  stock is  entitled  to one vote on all
matters.  No other class of securities  will be entitled to vote at the meeting.
There are no cumulative voting rights.

         The six  nominees  receiving  the  highest  number of votes cast by the
holders of common stock represented and voting at the meeting will be elected as
Hemispherx's   directors  and  constitute  the  entire  board  of  directors  of
Hemispherx.  The  affirmative  vote  of  at  least  a  majority  of  the  shares
represented and voting at the annual meeting at which a quorum is present (which
shares voting  affirmatively also constitute at least a majority of the required
quorum) is necessary  for approval of Proposals  No. 2, 3 and 4. Pursuant to the
AMEX Company Guide, votes on Proposal No. 3 by Company  stockholders who own the
debentures  and  warrants  referred to in that  Proposal may not be counted with
regard to that Proposal.











REVOCABILITY OF PROXIES

         If you  attend  the  meeting,  you may vote in  person,  regardless  of
whether  you have  submitted  a  proxy.  Any  person  giving a proxy in the form
accompanying  this proxy statement has the power to revoke it at any time before
it is voted.  It may be revoked  by  filing,  with the  corporate  secretary  of
Hemispherx  at  its  principal   offices,   1617  JFK   Boulevard,   Suite  660,
Philadelphia,  PA 19103, a written notice of revocation or a duly executed proxy
bearing a later date,  or it may be revoked by attending  the meeting and voting
in person.

VOTING AND SOLICITATION

         Every  stockholder  of record is entitled,  for each share held, to one
vote on each  proposal  or item that  comes  before  the  meeting.  There are no
cumulative  voting rights.  By submitting your proxy,  you authorize  William A.
Carter and Ransom W.  Etheridge  and each of them to represent you and vote your
shares at the meeting in accordance with your instructions.  Messrs.  Carter and
Etheridge and each of them may also vote your shares to adjourn the meeting from
time to time and will be  authorized to vote your shares at any  adjournment  or
postponement of the meeting.

         Hemispherx has borne the cost of preparing, assembling and mailing this
proxy solicitation  material. The total cost estimated to be spent and the total
expenditures  to  date  for,  in  furtherance  of,  or in  connection  with  the
solicitation of stockholders is approximately $40,000.  Hemispherx may reimburse
brokerage firms and other persons  representing  beneficial owners of shares for
their expenses in forwarding soliciting materials to beneficial owners.  Proxies
may be solicited by certain of Hemispherx's  directors,  officers and employees,
without additional compensation, personally, by telephone or by facsimile.

         We have hired the firm of  MacKenzie  Partners,  Inc.  to assist in the
solicitation  of  proxies  on behalf of the Board of  Directors.  MacKenzie  has
agreed to perform this  service for a proposed fee of $5,000 plus  out-of-pocket
expenses.

ADJOURNED MEETING

         The chair of the meeting  may adjourn the meeting  from time to time to
reconvene  at the same or some other  time,  date and place.  Notice need not be
given of any such  adjournment  meeting if the time,  date and place thereof are
announced at the meeting at which the  adjournment is taken.  If the time,  date
and place of the adjournment  meeting are not announced at the meeting which the
adjournment is taken,  then the Secretary of the Corporation  shall give written
notice of the time, date and place of the adjournment  meeting not less than ten
(10)  days  prior  to  the  date  of  the  adjournment  meeting.  Notice  of the
adjournment  meeting also shall be given if the meeting is adjourned in a single
adjournment to a date more than 30 days or in successive  adjournments to a date
more than 120 days after the original date fixed for the meeting.

TABULATION OF VOTES

         The votes will be  tabulated  and  certified by  Hemispherx's  transfer
agent.

VOTING BY STREET NAME HOLDERS

         If you are the  beneficial  owner of shares held in "street  name" by a
broker,  the broker,  as the record  holder of the  shares,  is required to vote
those  shares  in  accordance  with  your  instructions.  If  you  do  not  give
instructions to the broker, the broker will nevertheless be entitled to vote the
shares with respect to  "discretionary"  items but will not be permitted to vote
the shares with respect to "non-discretionary"  items (in which case, the shares
will be treated as "broker non-votes").


QUORUM; ABSTENTIONS; BROKER NON-VOTES

         The  required  quorum for the  transaction  of  business  at the annual
meeting is a  majority  of the shares of common  stock  entitled  to vote at the
annual meeting, in person or by proxy. Shares that are voted "FOR," "AGAINST" or
"WITHHELD  FROM" a matter  are  treated  as being  present  at the  meeting  for
purposes of establishing a quorum and are also treated as shares represented and
voting the votes cast at the annual meeting with respect to such matter.

         While  there  is no  definitive  statutory  or case  law  authority  in
Delaware as to the proper  treatment of  abstentions,  Hemispherx  believes that
abstentions should be counted for purposes of determining both: (i) the presence
or absence  of a quorum  for the  transaction  of  business;  and (ii) the total
number of votes cast with  respect to a proposal  (other  than the  election  of
directors). In the absence of controlling precedent to the contrary,  Hemispherx
intends to treat abstentions in this manner. Accordingly,  abstentions will have
the same effect as a vote  against  the  proposal  (other  than the  election of
directors).

         Under current Delaware case law, while broker non-votes (i.e. the votes
of shares held of record by brokers as to which the underlying beneficial owners
have given no voting instructions) should be counted for purposes of determining
the  presence or absence of a quorum for the  transaction  of  business,  broker
non-votes  should not be counted for purposes of determining the number of votes
cast with respect to the  particular  proposal on which the broker has expressly
not voted.  Hemispherx intends to treat broker non-votes in this manner. Thus, a
broker  non-vote  will make a quorum  more  readily  obtainable,  but the broker
non-vote will not otherwise affect the outcome of the voting on a proposal.

DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS


         Proposals of  stockholders  to be considered for inclusion in the Proxy
Statement  and proxy card for the 2005 Annual  Meeting of  Stockholders  must be
received by the Company's  Secretary,  at Hemispherx  Biopharma,  Inc., 1617 JFK
Boulevard, Philadelphia, PA 19103 no later than , 2005.


         Pursuant to the Company's  Restated and Amended Bylaws all  stockholder
proposals  may be brought  before an annual  meeting of  stockholders  only upon
timely notice thereof in writing having been given the Secretary of the Company.
To be timely, a stockholder's  notice, for all stockholder  proposals other than
the nomination of candidates  for director,  shall be delivered to the Secretary
at the principal  executive  offices of the Company not less than sixty (60) nor
more than  ninety  (90) days prior to the  anniversary  date of the  immediately
preceding annual meeting of stockholders;  provided,  however, that in the event
that the annual meeting is called for a date that is not within thirty (30) days
before or after such anniversary date, the  stockholder's  notice in order to be
timely  must be so  received  not later than the close of  business on the tenth
(10th)  day  following  the day on which  such  notice of the date of the annual
meeting was mailed or public  disclosure  of the date of the annual  meeting was
made, whichever first occurs. To be timely, a stockholder's notice, with respect
to a stockholder  proposal for nomination of candidates  for director,  shall be
delivered to the Secretary at the principal executive offices of the Company not
less than ninety (90) nor more than one hundred  twenty  (120) days prior to the
anniversary  date of the immediately  preceding  annual meeting of stockholders;
provided,  however,  that in the event that the  annual  meeting is called for a
date that is not within thirty (30) days before or after such anniversary  date,
the  stockholder's  notice in order to be timely must be so  received  not later
than the close of business on the tenth  (10th) day  following  the day on which
such notice of the date of the annual meeting was mailed or public disclosure of
the date of the annual  meeting  was made,  whichever  first  occurs.  Provided,
however, in the event that the stockholder proposal relates to the nomination of
candidates  for  director and the number of directors to be elected to the Board
of  Directors of the Company at an annual  meeting is increased  and there is no
public  announcement  by the Company  naming all of the nominees for director or
specifying  the size of the  increased  Board of  Directors at least one hundred
days prior to the first  anniversary of the preceding  year's annual meeting,  a
stockholder's  notice shall also be considered  timely, but only with respect to
nominees  for  any new  positions  created  by such  increase,  if it  shall  be
delivered to the Secretary at the principal executive offices of the Company not
later than the close of  business  on the tenth day  following  the day on which
such public announcement is first made by the Company. All stockholder proposals
must contain all of the information  required under the Company's Bylaws, a copy
of which is available upon written  request,  at no charge,  from the Secretary.
The  Company  reserves  the right to  reject,  rule out of order,  or take other
appropriate  action with respect to any proposal that does not comply with these
and other applicable requirements.





                            PROPOSALS TO STOCKHOLDERS

                                 PROPOSAL NO. 1
                              ELECTION OF DIRECTORS

         Each nominee to the board of directors will serve until the next annual
meeting of stockholders, or until his earlier resignation,  removal from office,
death or incapacity.

     Unless  otherwise  specified,  the enclosed proxy will be voted in favor of
the  election  of William A.  Carter,  Richard C.  Piani,  Ransom W.  Etheridge,
William M.  Mitchell,  Iraj-Eqhbal  Kiani,  and Antoni  Esteve.  Information  is
furnished below with respect to all nominees.

         Set forth below is the  biographical  information  of the  nominees and
directors of Hemispherx:

     WILLIAM A. CARTER, M.D., 66, the co-inventor of Ampligen, joined Hemispherx
in 1978, and has served as: (a) Hemispherx's  Chief Scientific Officer since May
1989; (b) the Chairman of  Hemispherx's  Board of Directors  since January 1992;
(c)  Hemispherx's  Chief  Executive  Officer since July 1993;  (d)  Hemispherx's
President  since April,  1995; and (e) a director since 1987. From 1987 to 1988,
Dr. Carter served as Hemispherx's  Chairman.  Dr. Carter was a leading innovator
in the  development of human  interferon for a variety of treatment  indications
including  various viral diseases and cancer.  Dr. Carter received the first FDA
approval to initiate clinical trials on beta interferon product  manufactured in
the U.S. under his supervision.  From 1985 to October 1988, Dr. Carter served as
Hemispherx's  Chief Executive Officer and Chief Scientist.  He received his M.D.
degree from Duke  University  and  underwent his  post-doctoral  training at the
National  Institutes  of Health and Johns  Hopkins  University.  Dr. Carter also
served as Professor of Noeplastic  Diseases at Hahnemann Medical  University,  a
position he held from 1980 to 1998.  Dr.  Carter  served as Director of Clinical
Research  for  Hahnemann  Medical  University  Institute  for  Cancer  and Blood
Diseases,  and as a professor at Johns Hopkins  School of Medicine and the State
University of New York at Buffalo. Dr. Carter is a Board certified physician and
author of more than 200  scientific  articles,  including the editing of various
textbooks on anti-viral and immune therapy.

     RICHARD C. PIANI, 77, has been a director of Hemispherx since May 1995. Mr.
Piani was  employed as a principal  delegate for Industry to the City of Science
and Industry,  Paris,  France, a scientific and educational  complex,  from 1985
through 2000. Mr. Piani provided  consulting to Hemispherx in 1993, with respect
to general business strategies for Hemispherx's European operations and markets.
Mr.  Piani  served as Chairman of  Industrielle  du  Batiment-Morin,  a building
materials  corporation,  from 1986 to 1993. Previously Mr. Piani was a Professor
of International  Strategy at Paris Dauphine  University from 1984 to 1993. From
1979 to 1985, Mr. Piani served as Group Director in Charge of International  and
Commercial  Affairs for  Rhone-Poulenc and from 1973 to 1979 he was Chairman and
Chief  Executive  Officer of Societe "La  Cellophane",  the French company which
invented  cellophane and several other worldwide  products.  Mr. Piani has a Law
degree  from  Faculte de Droit,  Paris  Sorbonne  and a Business  Administration
degree from Ecole des Hautes Etudes Commerciales, Paris.

     RANSOM W.  ETHERIDGE,  64, has been a director of Hemispherx  since October
1997, and presently serves as our secretary and general  counsel.  Mr. Etheridge
first became  associated  with  Hemispherx  in 1980 when he provided  consulting
services  to  Hemispherx  and  participated  in  negotiations  with  respect  to
Hemispherx's  initial  private  placement  through  Oppenheimer  & Co., Inc. Mr.
Etheridge has been practicing law since 1967, specializing in transactional law.
Mr.  Etheridge is a member of the Virginia State Bar, a Judicial  Remedies Award
Scholar and has served as President of the Tidewater Arthritis Foundation. He is
a graduate of Duke University and the University of Richmond School of Law.

     WILLIAM M.  MITCHELL,  M.D.,  69, has been a director  since July 1998. Dr.
Mitchell  is a  Professor  of  Pathology  at  Vanderbilt  University  School  of
Medicine.  Dr.  Mitchell  earned an M.D. from  Vanderbilt and a Ph.D. from Johns
Hopkins University,  where he served as an Intern in Internal Medicine, followed
by a Fellowship at its School of Medicine.  Dr.  Mitchell has published over 200
papers,  reviews and abstracts  dealing with viruses and anti-viral  drugs.  Dr.
Mitchell  has worked for and with many  professional  societies,  including  the
International  Society for Interferon Research,  and committees,  among them the
National  Institutes of Health,  AIDS and Related  Research  Review  Group.  Dr.
Mitchell previously served as a director of Hemispherx from 1987 to 1989.

     IRAJ-EQHBAL  KIANI,  M.B.A.,  PH.D.,  58,  was  appointed  to the  Board of
Directors  on May 1, 2002.  Dr.  Kiani is a citizen of  England  and  resides in
Newport,  California.  As a native of Iran,  Dr. Kiani  served in various  local
government  positions  including the Governor of Yasoi,  Capital of  Boyerahmad,
Iran.  In 1980,  Dr. Kiani moved to England,  where he  established  and managed
several  trading  companies  over a  period  of some 20  years.  Dr.  Kiani is a
planning  and  logistic  specialist  who  is  now  applying  his  knowledge  and
experience to build a worldwide  immunology network which will use the Company's
proprietary technology.  Dr. Kiani received his Ph.D. degree from the University
of Warwick in England.

     ANTONI  ESTEVE,  Ph.D.,  45,  became a member of our Board of  Directors in
November 2003. Dr. Esteve is a Member of the Executive Committee and Director of
Scientific and Commercial Operations for Laboratorios del Dr. Esteve S.A. He has
been  engaged  at  Laboratorios  del Dr.  Esteve  since  1984.  Since 1986 he is
Professor at the Autonomous University of Barcelona, School of Pharmacy. In 2001
he was elected as member of the Advisory  Board for R&D of the Spanish  Ministry
of Science and  Technology.  Since 2002 he also has been  President of Centre de
Transfussio  i Banc de Teixits  (the  Transfusion  and  Tissues  Bank  Center of
Catalonia).  Dr.  Esteve  received a degree in Pharmacy  from the  University of
Barcelona, Faculty of Pharmacy, in 1981 and a Ph.D. in Pharmaceutical Science in
1990.

     THE BOARD OF DIRECTORS  DEEMS PROPOSAL NO. 1 TO BE IN THE BEST INTERESTS OF
HEMISPHERx  AND ITS  STOCKHOLDERS  AND  RECOMMENDS  A VOTE  "FOR" ALL SIX OF THE
ABOVE-NAMED NOMINEE DIRECTORS OF HEMISPHERX.









                      INFORMATION CONCERNING BOARD MEETINGS

         Hemispherx  board  of  directors  met four  times  and  executed  three
Unanimous  Consents,  the  Compensation  Committee  met  two  times,  the  Audit
Committee  met four times,  and the Strategic  Planning  Committee met two times
during the fiscal year ended December 31, 2003. Four of the incumbent  directors
attended  100% of the Board  Meetings  and one  incumbent,  Iraj  Eqhbal  Kiani,
attended two meetings.

                 INFORMATION CONCERNING COMMITTEES OF THE BOARD

         The board of directors maintains the following committees:

Executive Committee.

         The  Executive  Committee  is  composed  of  William A.  Carter,  Chief
Executive  Officer and President,  Ransom W. Etheridge,  Secretary and director,
and  Iraj-Eqhbal  Kiani.  The  Executive  Committee  makes   recommendations  to
management regarding general business matters of Hemispherx.

Compensation Committee.

         The  Compensation  Committee  is  composed  of  Dr.  William  Mitchell,
director,  and Richard C. Piani,  director.  The  Compensation  Committee  makes
recommendations  concerning  salaries  and  compensation  for  employees  of and
consultants to Hemispherx.

Nominating Committee.

         The  Nominating  Committee  is composed of Dr.  William  Mitchell,  Dr.
Iraj-Eqhbal Kiani and Richard Piani, all determined by the Board of Directors to
be  independent  directors  under the AMEX  Company  Guide.  This  Committee  is
responsible for  recommending to the Board the slate of nominees to be put forth
for election by the  stockholders  at our annual  meeting.  This  Committee also
reviews  proposals  for  nominations  from  stockholders  that are  submitted in
accordance with the procedures published in our proxy statement.

         The  Nominating  Committee  does  not  currently  have a  charter.  The
committee utilizes a subjective  analysis to identify and evaluate candidates to
be  nominated  as  directors,  including  but not limited to,  general  business
knowledge,  experience  with  financial  reporting,  interest  in the  Company's
business and related marketing  businesses,  and willingness to serve.  However,
there are  currently no minimum  qualifications  or  standards  that the Company
seeks for director nominees.  The Company does not engage or pay any third party
to assist in the process of identifying or evaluating  candidates for a director
position.   The  Company  would  consider   candidates  for  director   nominees
recommended by stockholders in accordance with the requirements of Delaware law.
If stockholder  nominations were made, the Nominating Committee would perform an
investigation  of the candidate to determine if the candidate were qualified and
would present the stockholder nomination in the proxy statement to be subject to
a vote of the stockholders.

Audit Committee and Audit Committee Expert.

     Hemispherx's  Audit Committee of the Board of Directors consists of Richard
Piani, Committee Chairman, William Mitchell, M.D. and Iraj Eqhbal Kiani, M.B.A.,
Ph.D. Mr. Piani, Dr. Mitchell and Dr.  Iraj-Eqhbal  Kiani, all determined by the
Board of Directors to be independent  directors under Section  121B(2)(a)(i)  of
the AMEX Company Guide.  Hemispherx does not have a financial  expert as defined
in Securities and Exchange  Commission  rules on the committee in the true sense
of the  description.  However,  Mr. Piani is a  businessman  and has 40 years of
experience working with budgets, analyzing financials and dealing with financial
institutions.  Hemispherx believes Mr. Piani, Dr. Mitchell and Iraj Eqhbal Kiani
to be  independent  of  management  and  free  of any  relationship  that  would
interfere  with  their  exercise  of  independent  judgment  as  members of this
committee.  The principal  functions of the Audit  Committee are to (i) annually
recommend independent accountants, (ii) prepare the reports or statements as may
be  required  by AMEX or the  securities  laws,  (iii)  review the  adequacy  of
Hemispherx's  system of internal  accounting  controls and Hemispherx's  audited
financial  statements and reports,  (iv) discuss the statements and reports with
management,  including any  significant  adjustments,  management  judgments and
estimates,  new accounting policies and disagreements with management,  and (vi)
review  disclosures by independent  accountants  concerning  relationships  with
Hemispherx and the performance of Hemispherx's independent accountants.

         The Board of Directors is currently  reviewing the charter of the Audit
Committee  and plan to vote on an  updated  and  revised  charter  at the  Board
Meeting scheduled for June 23, 2004.

Audit Committee Report.

         The primary  responsibility of the Audit Committee (the "Committee") is
to assist the Board of Directors in discharging  its oversight  responsibilities
with respect to financial matters and compliance with laws and regulations.  The
primary methods used by the Committee to fulfill its responsibility with respect
to financial matters are:

     o To  appoint,  evaluate,  and,  as the  Committee  may  deem  appropriate,
terminate and replace our independent auditors;

     o To monitor the independence of our independent auditors;

     o To determine the compensation of our independent auditors;

     o To pre-approve any audit services,  and any non-audit  services permitted
under applicable law, to be performed by our independent auditors;

     o To review our risk exposures, the adequacy of related controls and
              policies with respect to risk assessment and risk management;

     o To monitor the integrity of our financial reporting processes and systems
of control  regarding  finance,  accounting,  legal  compliance and  information
systems;

     o To  facilitate  and  maintain an open avenue of  communication  among the
Board of Directors, management and our independent auditors.

         The Audit Committee is composed of three  directors,  and the Board has
determined  that each of those  directors is independent as that term is defined
in Sections 121(B)(2)(a)(i) of the American Stock Exchange Company Guide.

     In March 2004, the Board re-elected Mr. Piani, Dr. Mitchell and Iraj-Eqhbal
Kiani to the Audit Committee effective March 11, 2004, subject to their election
to the Board by stockholders at the Annual Meeting.

         The Committee has met four times in 2003.

         In  discharging  its  responsibilities  relating to internal  controls,
accounting  and  financial  reporting  policies  and  auditing  practices,   the
Committee discussed with our independent auditor, BDO Seidman,  LLP, the overall
scope and process for its audit. The Committee regularly meets with BDO Seidman,
LLP,  with and  without  management  present,  to  discuss  the  results  of its
examinations,  the evaluations of our internal  controls and the overall quality
of our financial reporting.

         The Committee has discussed with BDO Seidman,  LLP its judgments  about
the quality, in addition to the acceptability,  of our accounting  principles as
applied in our  financial  reporting,  as  required  by  Statement  on  Auditing
Standards No. 61 "Communications with Audit Committees."

         The Committee also has received the written  disclosures and the letter
from BDO Seidman, LLP that is required by Independence  Standards Board Standard
No. 1, Independence  Discussions with Audit  Committees,  and has discussed with
BDO Seidman, LLP their independence.

         The  Committee  has met  and  held  discussions  with  management.  The
Committee  has reviewed  and  discussed  with  management  Hemispherx's  audited
consolidated  financial  statements as of and for the fiscal year ended December
31, 2002 and the audited  consolidated  financial  statements  as of and for the
fiscal year ended December 31, 2003.

         Based on the reviews and discussions  referred to above,  the Committee
recommended  to the Board of  Directors  that the audited  financial  statements
referred to above be included in our  Informational  Statement and Annual Report
for the year ended December 31, 2003.

         This  report is  respectfully  submitted  by the  members  of the Audit
Committee of the Board of Directors.


                           Richard C. Piani, Chairman
                               William M. Mitchell
                                Iraj-Eqhbal Kiani

Code of Ethics

Hemispherx's  Board of Directors  adopted a code of ethics and business  conduct
for officers,  directors  and  employees  that went into effect on May 19, 2003.
This  code has  been  presented  and  reviewed  by each  officer,  director  and
employee.  You may  obtain  a copy of this  code  by  visiting  our web  site at
www.hemispherx.net  or by written  request to our office at 1617 JFK  Boulevard,
Suite 660, Philadelphia, PA 19103. Our board of directors is required to approve
any  waivers  of the code of  ethics  and  business  conduct  for  directors  or
executive  officers and we are  required to disclosed  any such waiver in a Form
8-K within five days.

Strategic Planning Committee.

         The Strategic  Planning  Committee is composed of William A. Carter and
Richard C. Piani. The Strategic Planning Committee makes  recommendations to the
board of directors of priorities in the  application of  Hemispherx's  financial
assets  and  human   resources  in  the  fields  of  research,   marketing   and
manufacturing.  The Strategic Planning Committee has engaged a number of leading
consultants in healthcare, drug development and pharmaeconomics to assist in the
analysis of various products being developed and/or potential acquisitions being
considered by Hemispherx.


Communication with the Board of Directors

         Interested  parties  wishing to contact the board of  directors  of the
Company may do so by writing to the following address:  Board of Directors,  c/o
Ransom  Etheridge,  Director,  Corporate  Secretary  and General  Counsel,  2610
Potters Rd.,  Virginia Beach, VA 23452. All letters received will be categorized
and  processed by the Corporate  Secretary  and then  forwarded to the Company's
Board or Directors.


Director Attendance at Annual Meetings of Shareholders

         Directors  are  encouraged,  but not  required,  to attend  the  Annual
Meeting of  Stockholders.  At the 2003 Annual Meeting,  four of the five sitting
directors were in attendance.

                    INFORMATION CONCERNING EXECUTIVE OFFICERS

         The following sets forth  biographical  information about  Hemispherx's
executive officers and key personnel:

         Name                     Age    Position
        -----------------------   ----   --------------------------------------
         William A. Carter, M.D.   66    Chairman, Chief Executive Officer, and
                                         President
         Robert E. Peterson        67    Chief Financial Officer

         David R. Strayer, M.D.    58    Medical Director, Regulatory Affairs

         Mei-June Liao, Ph.D.      53    Vice President of Regulatory Affairs,
                                         Quality Control and
                                         Research and Development
         Robert Hansen             60    Vice President of Manufacturing

         Carol A. Smith, Ph.D.     54    Director of Process Development

         Ransom W. Etheridge       64    Secretary and General Counsel


     For  biographical  information  about  William A.  Carter,  M.D. and Ransom
Etheridge,  please see the discussion under the heading "Proposal No. 1 Election
of Directors" above.

     ROBERT E.  PETERSON  has served as Chief  Financial  Officer of the Company
since April 1993 and served as an Independent  Financial  Advisor to the Company
from 1989 to April 1993.  Also, Mr. Peterson has served as Vice President of the
Omni Group,  Inc., a business  consulting  group based in Tulsa,  Oklahoma since
1985.  From 1971 to 1984, Mr.  Peterson  worked for PepsiCo,  Inc. and served in
various  financial  management  positions  including  Vice  President  and Chief
Financial  Officer of PepsiCo Foods  International  and PepsiCo  Transportation,
Inc. Mr. Peterson is a graduate of Eastern New Mexico University.

     DAVID R.  STRAYER,  M.D. who served as Professor of Medicine at the Medical
College of  Pennsylvania  and  Hahnemann  University,  has acted as the  Medical
Director of the Company  since 1986. He is Board  Certified in Medical  Oncology
and Internal Medicine with research interests in the fields of cancer and immune
system  disorders.  Dr. Strayer has served as principal  investigator in studies
funded by the Leukemia Society of America,  the American Cancer Society, and the
National  Institutes of Health.  Dr. Strayer  attended the School of Medicine at
the University of California at Los Angeles where he received his M.D. in 1972.

     MEI-JUNE LIAO,  Ph.D.  has served as Vice President of Regulatory  Affairs,
Quality and Research & Development  since October 2003 and as Vice  President of
Research  &  Development  since  March  2003  with   responsibilities   for  the
regulatory,  quality control and product  development of Alferon(R).  Before the
acquisition  of certain  assets of ISI, Dr. Liao was Vice  President of Research
and Development  from 1995 to 2003 and held senior positions in the Research and
Development  Department  of ISI from 1983 to 1994.  Dr. Liao  received her Ph.D.
from Yale University in 1980 and completed a three year postdoctoral appointment
at the  Massachusetts  Institute  of  Technology  under the  direction  of Nobel
Laureate in Medicine,  Professor H. Gobind  Khorana.  Dr. Liao has authored many
scientific publications and invention disclosures.

ROBERT HANSEN joined the Company as Vice President of Manufacturing in 2003 upon
the  acquisition of certain assets of ISI. He is responsible for the manufacture
of Alferon N(R).  Mr. Hansen had been Vice  President of  Manufacturing  for ISI
since 1997, and served in various capacities in manufacturing  since joining ISI
in 1987. He has a B.S. degree in Chemical  Engineering from Columbia  University
in 1966.

     CAROL A. SMITH, Ph.D. has served as the Company's Director of Manufacturing
and Process  Development  since April 1995, as Director of Operations since 1993
and as the Manager of Quality Control from 1991 to 1993, with responsibility for
the   manufacture,   control  and  chemistry  of  Ampligen(R).   Dr.  Smith  was
Scientist/Quality  Assurance Officer for Virotech International,  Inc. from 1989
to 1991 and Director of the Reverse  Transcriptase  and Interferon  Laboratories
and a Clinical  Monitor for Life Sciences,  Inc. from 1983 to 1989. She received
her Ph.D.  from the University of South Florida  College of Medicine in 1980 and
was an NIH post-doctoral  fellow at the Pennsylvania State University College of
Medicine.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         Ransom W.  Etheridge,  an officer and  director of the  Company,  is an
attorney in private  practice who has rendered  corporate  legal  services to us
from time to time,  for  which he has  received  fees.  Mr.  Etheridge  received
$60,000 for his professional services in 2003.

         Richard C. Piani, a director of the Company, lives in Paris, France and
assists  the  Company's  European  subsidiary  in their  dealings  with  medical
institutions and the European Medical Evaluation Authority. William M. Mitchell,
M.D.,  another director of the Company,  works with David R. Strayer,  M.D. (the
Company's Medical Director) in establishing  clinical trial protocols as well as
other  scientific  work for the Company from time to time.  For these  services,
these two directors were paid an aggregate of $40,100 in the year 2003.  William
A. Carter,  Chief  Executive  Officer of the  Company,  received an aggregate of
$12,106 in short term  advances  in 2002 which were  repaid as of  December  31,
2002.  The Company  loaned  $60,000 to Mr.  Etheridge  in November  2001 for the
purpose  of  exercising  15,000  Class A  Redeemable  warrants.  This loan bears
interest at 6% per annum.  Dr. Carter's short term advances and Mr.  Etheridge's
loan were approved by the Board of Directors.

         The Company  paid  $57,750,  $33,450  and $18,800 for the years  ending
December 31, 2001, 2002 and 2003, respectively, to Carter Realty for the rent of
property used at various times in 2001,  2002 and 2003. The property is owned by
others and managed by Carter  Realty.  Carter Realty is owned by Robert  Carter,
the brother of William A. Carter, the Company's Chief Executive Officer.

     Antoni Esteve, one of the Company's directors, is a member of the Executive
Committee and Director of Scientific and Commercial  Operations of  Laboratorios
Del Dr. Esteve S.A. In March 2002, the Company's European subsidiary  Hemispherx
S.A. entered into a Sales and Distribution  Agreement with  Laboratorios Del Dr.
Esteve S.A. In addition, in March 2003, we issued 347,445 shares of common stock
to Provesan S.A., an affiliate of Laboratorios  Del Dr. Esteve S.A., in exchange
for 1,000,000 Euros of convertible  preferred equity  certificates of Hemispherx
S.A., owned by Laboratorios Del Dr. Esteve S.A.

         There are no material  proceedings  to which any  officer,  director or
affiliate,  or any associate  thereof is a party adverse to the Company or has a
material interest adverse to the Company.

                COMPLIANCE WITH SECTION 16(a) OF THE EXCHANGE ACT

         Section  16(a) of the Exchange Act requires  Hemispherx's  officers and
directors,  and persons who own more than ten percent of a  registered  class of
Hemispherx's equity securities, to file reports with the Securities and Exchange
Commission  reflecting their initial position of ownership on Form 3 and changes
in ownership on Form 4 or Form 5.

         Based  solely  on a review  of the  copies of such  forms  received  by
Hemispherx,  Hemispherx believes that, during the fiscal year ended December 31,
2003,  its officers,  directors and ten percent  stockholders  complied with all
applicable Section 16(a) filing  requirements on a timely basis, except that Dr.
Carter,  Dr.  Mitchell  and Mr.  Piani  each  filed a Form 5 late in which  each
reported one transaction that should have been reported on a Form 4 during 2003;
Mr.  Etheridge  filed a Form 5 late in which he reported two  transactions  that
should have been reported on a Form 4 during 2003; and Dr. Esteve and Mr. Kiani,
we have been informed, are each in the process of filing a Form 3.

                COMPENSATION OF EXECUTIVE OFFICERS AND DIRECTORS

         The  summary   compensation   table  below  sets  forth  the  aggregate
compensation  paid or accrued by Hemispherx  for the fiscal years ended December
31, 2003, 2002 and 2001 to (i) the Chief Executive Officer and (ii) Hemispherx's
four most highly paid  executives  who were serving as  executives at the end of
the last completed  fiscal year and whose total annual salary and bonus exceeded
$100,000 (collectively, the "Named Executives").


                             EXECUTIVE COMPENSATION
                           SUMMARY COMPENSATION TABLE


Name and Principal     Year     Salary ($) Restricted  Warrants    All Other
  Position                                Stock Awards & Options   Compensation
                                                       Awards       (1)
--------------------- -------- ------------ -------   ------------ -----------
William A. Carter        2003  (4)$582,461  -         (5)1,450,000  $37,175
Chairman of the Board    2002  (4) 565,514  -         (8)1,000,000   25,747
and CEO                  2001  (4) 551,560  -         (2)  386,650   22,917


Robert E. Peterson       2003  (9)$230,450  -                  -       -
Chief Financial Officer  2002     151,055   -         (8)  200,000     -
                         2001     146,880   -         (3)   40,000     -

   2003
David R. Strayer, M.D.   2003  (6)$190,096  -         (8)   50,000     -
Medical Director         2002  (6) 178,594  -         (7)   10,000     -
                         2001  (6) 174,591  -

Carol A. Smith, Ph.D.    2003     $140,576  -                  -       -
  Director of            2002      128,346  -         (8)   20,000     -
Manufacturing            2001      124,800  -         (7)   10,000     -


Robert Hansen, V.P. of   2003 (10)$104,500  -                  -       -
Manufacturing            2002          -    -                  -       -
                         2001          -    -                  -       -


(1)      Consists of insurance premiums paid by us with respect to term life and
         disability insurance for the benefit of the named executive officer.

(2)      Consists  of 188,325  warrants to  purchase  common  stock at $6.00 per
         share and 188,325 warrants to purchase common stock at $9.00 per share.
         Also  includes a stock option  grant of 10,000  shares  exercisable  at
         $4.03 per share.

(3)      Consist of a stock option grant of 10,000 shares  exercisable at $4.03
         per share and 30,000  warrants to purchase common stock
         at $5.00 per share.

(4)      Includes  bonuses of $94,952,  $96,684  and  $99,481 in 2001,  2002 and
         2003,  respectively.  Also includes funds previously paid to Dr. Carter
         by Hahnemann  Medical  University  where he served as a professor until
         1998.  This  compensation  was  continued by us and totaled  $79,826 in
         2001, $82,095 in 2002 and $84,776 in 2003.

(5)      Represents warrants to purchase common stock exercisable at $2.20 per
         share.

(6)      Includes $98,926 paid by Hahnemann Medical University where Dr. Strayer
         served as a professor until 1998. This compensation
         was continued by us in 2001, 2002 and 2003.

(7)      Consist of stock option grant of 10,000 shares exercisable at $4.03 per
         share.

(8)      Represents number of warrants to purchase shares of common stock at
         $2 per share.

(9)      2003 includes a bonus of $74,464 paid in 2004.

(10)     Compensation since March 2003. Employed by ISI prior to that.

         The following  table sets forth  certain  information  regarding  stock
warrants  granted  during 2003 to the  executive  officers  named in the Summary
Compensation Table.

                 INDIVIDUAL GRANTS
------     ---------------------------- -------- ---------- -------------------
------     ------------ --------------- -------- ---------- -------------------
NAME        NUMBER OF   PERCENTAGE OF   EXERCISE EXPIRATION POTENTIAL REALIZABLE
                        TOTAL WARRANTS           DATE       VALUE AT ASSUMED
            SECURITIES  GRANTED TO                          RATES OF
            UNDERLYING  EMPLOYEES IN                        STOCK PRICE
            WARRANTS    FISCAL YEAR     PRICE PER           APPRECIATION
            GRANTED (1) 2002(2)         SHARE (3)           FOR WARRANTS TERM
------      ----------- -------------- --------- ---------- ------------------
------      ----------- -------------- --------- ---------- --------- ---------
                                                             5% (4)    10%(4)
------      ----------- -------------- --------- ---------- --------- ---------
------      ----------- -------------- --------- ---------- --------- ---------
Carter, W.A.1,450,000   100%           $2.20     9/8/08   $4,071,338 $5,137,527
------      ----------- -------------- --------- ---------- --------- ---------

(1)  These warrants  became  exercisable on March 17, 2004,  when the second ISI
     acquisition was completed.

(2)  Total warrants issued to employees in 2003 were 1,450,000.

(3)  The exercise  price is equal to the closing price of the  Company's  common
     stock at the date of issuance.

(4)  Potential  realizable value is based on an assumption that the market price
     of the common stock  appreciates at the stated rates  compounded  annually,
     from the date of grant until the end of the respective  option term.  These
     values are calculated  based on requirements  promulgated by the Securities
     and  Exchange  Commission  and do not reflect our  estimate of future stock
     price appreciation.




         The following table sets forth certain information  regarding the stock
options  held as of  December  31,  2003 by the  individuals  named in the above
Summary Compensation Table.

                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR-END OPTION VALUE


                          Securities Underlying Unexercised Value of Unexercised
                          Warrants/In-the-Money-Options  At Fiscal  Year
                          Options at Fiscal Year End   End (1)

                          Numbers                    Dollars

Name    Shares   Value    Exercisable Unexercisable Exercisable Unexercisable
        Acquired Realized
        on       ($)
        Exercise
        (#)
------- -------- -------- ----------- ------------- ---------- -------------
------- -------- -------- ----------- ------------- ---------- -------------

William
Carter   -        -       3,805,378(2)  1,950,000(3) $367,150   $217,000

Robert   -        -         403,750(4)   -             52,000       -
Peterson

David
Strayer  -        -         130,000(5)   -             13,000       -

Carol
Smith    -        -          41,791(6)   -              5,200       -
----------------------------

     (1) Computation based on $2.26, the December 31, 2003 closing bid price for
the common stock on the American Stock Exchange.

     (2) Consist of (i) 500,000 warrants exercisable at $2.00 per share expiring
on August 13, 2007 (ii) 188,325 warrants exercisable at $6.00 per share expiring
on  February  22, 2006 (iii)  188,325  warrants  exercisable  at $9.00 per share
expiring on February 22, 2006 (iv)  100,000  warrants  exercisable  at $6.25 per
share  expiring on April 8, 2004 (v) 25,000  warrants  exercisable  at $6.50 per
share expiring on September 17, 2004 (vi) 25,000  warrants  exercisable at $8.00
per share  expiring on September 17, 2004 (vii) 10,000 stock option  exercisable
at $4.03 per share  expiring on January 3, 2011,  (viii)  73,728  stock  options
exercisable at $2.71 per share until exercised. Also includes 2,695,000 warrants
and options held in the name of Carter Investments, L.C. of which W.A. Carter in
the principal  beneficiary.  These  securities  consist of (i) 340,000  warrants
exercisable at $4.00 per share expiring on January 1, 2008,(ii) 170,000 warrants
exercisable  at $5.00  per share  expiring  on  January  1,  2005,(iii)  300,000
warrants  exercisable at $6.00 per share expiring on January 1, 2005 (iv) 20,000
warrants  exercisable at $4.00 per share expiring on 2008,(v)  465,000  warrants
exercisable  at  $1.75  expiring  on  June  3,  2005,  and  1,400,000   warrants
exercisable at $3.50 per share expiring on October 16, 2004.

     (3)  Consists  of (i)  500,000  warrants  exercisable  at $2.00  per  share
expiring on August 13, 2007 and (ii) 1,450,000 warrants exercisable at $2.20 per
share expiring on September 8, 2008.

     (4) Consists of (i) 10,000  stock  options  exercisable  at $4.03 per share
expiring on January 3, 2011 (ii) 13,750 stock options  exercisable  at $3.50 per
share expiring on January 22, 2007, (iii) 200,000 warrants  exercisable at $2.00
per share expiring on August 13, 2007, (iv) 50,000 warrants exercisable at $3.50
expiring on March 1, 2006, (v) 100,000  warrants  exercisable at $5.00 per share
expiring  on April 14, 2006 and (vi) 30,000  warrants  exercisable  at $5.00 per
share expiring on February 28, 2009.

     (5) Consists of (i) 50,000 warrants exercisable at $2.00 per share expiring
on August 13, 2007, (ii) 50,000 warrants exercisable at $4.00 per share expiring
on February 28, 2008,  (iii) 10,000 stock options  exercisable at $4.03 expiring
on January 3, 2011 and (iv) 20,000 stock options  exercisable at $3.50 per share
expiring on January 22, 2007.

     (6) Consists of (I) 20,000 warrants exercisable at $2.00 per share expiring
on August 13, 2007, (ii) 5,000 warrants  exercisable at $4.00 per share expiring
on June 7, 2008,  (iii)  10,000  stock  options  exercisable  at $4.03 per share
expiring on January 3, 2016,  and (iv) 6,791 stock options  exercisable at $3.50
per share expiring on January 22, 2007.

New Plan Benefits

         It cannot be determined at this time what benefits or amounts,  if any,
will be received  by or  allocated  to any person or group of persons  under the
Company's  2004 Equity  Incentive  Plan (the " Equity  Incentive Plan "), if the
Equity  Incentive  Plan is adopted,  or what amounts would have been received by
any person or group of persons for the last fiscal year if the Equity  Incentive
Plan had been in effect. See "Proposal 4: Approval of the Hemispherx 2004 Equity
Incentive Plan."

         The following table gives  information  about our Common Stock that may
be issued upon the  exercise of options,  warrants  and rights  under all of our
equity compensation plans as of December 31, 2003.

962:
                 Number of Securities to Weighted-average  Number of securities
                 be issued upon exercise Exercise price of Remaining available
                 of outstanding options, Outstanding       forfuture issuance
                 warrants and rights     options, warrants under equity
                                         and rights        compensation plans
                                              ----------  (excluding securities
                                                           reflected in column
                                                           (a))
                                                           -----------

 Plan Category
 -------------

                        (a)               (b)                    (c)
977:

Equity compensation
plans approved by
security holders:     433,134         $  3.16                     -

Equity compensation
plans not approved     _                 _                        -
by security holders

Total                 433,134         $  3.16                     -


Employment Agreements

         Hemispherx  entered into an amended and restated  employment  agreement
with its President and Chief Executive Officer,  Dr. William A. Carter, dated as
of  December  3,  1998,  as  amended  in August  2003,  which  provided  for his
employment  until May 8, 2008 at an  initial  base  annual  salary of  $361,586,
subject to annual  cost of living  increases.  In  addition,  Dr.  Carter  could
receive an annual performance bonus of up to 25% of his base salary, at the sole
discretion of the board of directors.  Dr.  Carter will not  participate  in any
discussions concerning the determination of his annual bonus. Dr. Carter is also
entitled to an incentive bonus of 0.5% of the gross proceeds received by us from
any joint  venture  or  corporate  partnering  arrangement,  up to an  aggregate
maximum  incentive  bonus of $250,000 for all such  transactions.  Dr.  Carter's
agreement  also provides that he be paid a base salary and benefits  through May
8, 2004 if he is  terminated  without  "cause",  as that term is  defined in the
agreement.  This agreement was extended to May 8, 2008. Pursuant to his original
agreement,  as amended  on August 8, 1991,  Dr.  Carter was  granted  options to
purchase  73,728  shares of our common  stock at an exercise  price of $2.71 per
share.

         Hemispherx  entered into an amended and restated  engagement  agreement
with Robert E. Peterson dated April 1, 2001,  which provides for Mr.  Peterson's
employment as Hemispherx's Chief Financial Officer until December 31, 2003 which
has been  extended  six months,  at an annual base salary of $155,988  per year,
subject to annual cost of living  increases.  In addition,  Mr.  Peterson  shall
receive bonus compensation upon Federal Drug Administration approval of Ampligen
based on the  number  of years  of his  employment  by us up to the date of such
approval.  Mr. Peterson's  agreement also contains a provision for severance pay
equal to nine months compensation.

Compensation of Directors


         The  compensation  package  for members of the Board of  Directors  was
changed on September 9, 2003.  Board member  compensation  consists of an annual
retainer of $100,000 to be paid 50% in cash and 50% in Company common stock.  In
addition,  certain non-employee directors received some compensation in 2003 for
special project work performed on the Company's behalf.  All directors have been
granted options to purchase common stock under our 1990 Stock Option Plan and/or
Warrants to purchase common stock.  The Company  believes such  compensation and
payments are necessary in order for us to attract and retain  qualified  outside
directors.


1990 Stock Option Plan

         Hemispherx  1990 Stock Option Plan, as amended ("1990 Plan"),  provides
for the grant of options to  employees,  directors,  officers,  consultants  and
advisors  for the  purchase of up to an  aggregate  of 460,798  shares of common
stock. The 1990 plan is administered by the Compensation  Committee of the board
of directors,  which has complete  discretion to select eligible  individuals to
receive and to  establish  the terms of option  grants.  The number of shares of
common stock  available  for grant under the 1990 Plan is subject to  adjustment
for  changes in  capitalization.  As of  December  31,  2003,  no  options  were
available  for grants  under the 1990 plan.  This plan  remains in effect  until
terminated by the Board of Directors or until all options are issued.



401(K) Plan

         In December 1995,  Hemispherx  established a defined contribution plan,
effective January 1, 1995,  entitled the Hemispherx  Biopharma  employees 401(K)
Plan and Trust Agreement. All full time employees are eligible to participate in
the 401(K) plan following one year of employment. Subject to certain limitations
imposed by federal tax laws,  participants  are eligible to contribute up to 15%
of their salary (including bonuses and/or commissions) per annum.  Participants'
contributions  to  the  401(K)  plan  may be  matched  by  Hemispherx  at a rate
determined  annually by the board of  directors.  Each  participant  immediately
vests  in  his  or  her  deferred   salary   contributions,   while   Hemispherx
contributions  will vest over one year. In 2003,  Hemispherx  provided  matching
contributions to each employee for up to 6% of annual pay for a total of $34,000
for all eligible employees.

Compensation Committee Interlocks and Insider Participation

     During the fiscal year ended December 31, 2003, the members of Hemispherx's
Compensation Committee were Ransom W. Etheridge and Richard Piani. Mr. Etheridge
serves as  secretary  and  general  counsel  and he is an  attorney  in  private
practice and has rendered  legal  services to Hemispherx for which he received a
fee. Mr. Piani received fees for certain  consulting work performed in Europe on
Hemispherx's  behalf.  Mr.  Etheridge  was  paid  $60,000  for his  professional
services.

         Notwithstanding  anything to the contrary,  the following report of the
Compensation  Committee,  the report of the Audit  Committee  on page 8, and the
performance graph on page 21 shall not be deemed  incorporated by reference this
Proxy  Statement  into any filing under the Securities Act of 1933, or under the
Securities  Exchange  Act  of  1934,  except  to the  extent  that  the  Company
specifically incorporates this information by reference, and shall not otherwise
be deemed filed under such Acts.

         Compensation Committee Report on Compensation

         The Compensation  Committee makes  recommendations  concerning salaries
and compensation for Hemispherx employees and consultants.

         The following report of the compensation  committee discusses executive
compensation  policies  and the  basis  of the  compensation  paid to  executive
officers in 2003.

         In general,  the compensation  committee seeks to link the compensation
paid to  each  executive  officer  to the  experience  and  performance  of such
executive officer.  Within these parameters,  the executive compensation program
attempts  to  provide  an  overall  level  of  executive  compensation  that  is
competitive  with  companies  of  comparable  size and with  similar  market and
operating characteristics.

         There  are  three  elements  in  Hemispherx's   executive  compensation
program, all determined by individual and corporate performance:

o        Base salary
o        Annual incentive
o        Long-term incentive

Base Salary

         In  establishing  base salary  levels for  individual  executives,  the
Compensation  Committee will consider  factors such as the executive's  scope of
responsibility,   current  and  future   potential   performance,   and  overall
competitive positioning relative to comparable positions at other companies. The
objective  of the Company is to structure  salaries  that are  competitive  with
those of similarly situated companies.

         The Summary  Compensation  Table shows  amounts  earned  during 2003 by
Hemispherx executive officers.  The base compensation of such executive officers
is set by  terms  of the  employment  agreement  entered  into  with  each  such
executive officer.  Hemispherx established the base salaries for Chief Executive
Officer, Dr. William A. Carter under an employment agreement in December 3, 1998
(as amended on August 14,  2003),  which  provides for a base salary of $361,586
until  May 8,  2008.  Also,  Hemispherx  entered  into  an  extended  employment
agreement with Robert E. Peterson,  Chief Financial Officer for a base salary of
$155,988 until December 31, 2003, which was extended six months.  Dr. Carter and
Mr.  Peterson's  agreements  allow  for  annual  cost of living  increases.  Dr.
Carter's  compensation  also  includes  funds  previously  paid to Dr. Carter by
Hahnemann  Medical  University  where he served as a professor  until 1998. This
compensation  was continued by us and totaled  $79,826 in 2001,  $82,095 in 2002
and $84,776 in 2003.

Annual Incentive

         Annual  incentive  bonus  awards  are  granted  from  time  to  time to
executives in recognition of their  contribution  to the Company's  business and
operations,  as measured  against  competitors  of the company and the Company's
internal budgets and operating plans.

         Hemispherx's  Chief Executive  Officer and Chief Financial  Officer are
entitled  to an  annual  incentive  bonus  as  determined  by  the  compensation
committee  based on such  executive  officers'  performance  during the previous
calendar year. The cash bonus awarded to Hemispherx's Chief Executive Officer in
2003 and the cash  bonus  awarded  to the Chief  Financial  Officer in 2003 were
determined based on this provision in their employment agreements.

Long-Term Incentives

         The Company grants long-term  incentive awards  periodically to align a
significant  portion of the  executive  compensation  program  with  stockholder
interests over the long-term  through  encouraging  and  facilitating  executive
stock  ownership.  Executives  are  eligible  to  participate  in the  Company's
incentive  stock  option  plans.   Hemispherx's   Chief  Executive  Officer  and
President,  Dr. William Carter,  received a grant of 1,450,000 warrants in 2003.
These  warrants  are  exercisable  at $2.20 per share and expire on September 8,
2008, unless previously exercised.  These warrants vest upon consummation of the
second  ISI  asset  closing  or the  filing  by us  with  the  U.S.  Food & Drug
Administration of a new drug application,  whichever happens first. The warrants
vested on March 18, 2004, when the second ISI asset closing was consummated.

Chief Executive Officer Compensation

         The  Summary  Compensation  Table  shows that  during the year 2003 the
Company's  Chief Executive  Officer and President,  Dr. William A. Carter earned
$582,461 in base compensation pursuant to the terms of his employment agreement.
In addition,  Dr. Carter's  compensation in 2003 also includes funds  previously
paid by Hahnemann University where he served as a Professor until 1998.

         The   Compensation   Committee   believes  that  Dr.   Carter's   total
compensation is consistent with the median  compensation for CEO's in comparable
companies.  Factors reviewed by the Compensation  Committee's  assessment of the
Company's and the CEO's performance includes individual  performance,  growth in
revenue and expense  management  and  implementation  of the Company's  business
strategy.

Compliance With Internal Revenue Code Section 162(m).

         One of the factors the Compensation  Committee  considers in connection
with compensation  matters is the anticipated tax treatment to Hemispherx and to
the executives of the compensation  arrangements.  The  deductibility of certain
types of compensation  depends upon the timing of an executive's  vesting in, or
exercise of, previously granted rights. Moreover, interpretation of, and changes
in, the tax laws and other factors beyond the Compensation  Committee's  control
also affect the  deductibility  of compensation.  Accordingly,  the Compensation
Committee will not necessarily  limit executive  compensation to that deductible
under  Section  162(m) of the Code.  The  Compensation  Committee  will consider
various  alternatives to preserving the  deductibility of compensation  payments
and benefits to the extent consistent with its other compensation objectives.

           This report submitted by the Compensation Committee of the
                          Company's Board of Directors.

                                Richard C. Piani
                             Dr. William M. Mitchell






                       COMPARATIVE STOCK PERFORMANCE GRAPH

      The following graph compares the cumulative total  stockholder  return for
the  Company's  common  stock since  December 31, 1998 to the  cumulative  total
returns of (i) the  Standard & Poor's  Smallcap  600 Index and (ii) a peer group
index  for  the  same  period,  assuming  an  investment  of $100 in each of the
Company's  common stock,  the Standard & Poor's  Smallcap 600 Index and the peer
group index.
[GRAPHIC OMITTED][GRAPHIC OMITTED]

                      ASSUMES $100 INVESTED ON JAN. 1, 1998
                           ASSUMES DIVIDEND REINVESTED
                        FISCAL YEAR ENDING DEC. 31, 2003

                            ANNUAL RETURN PERCENTAGE
                                  Years Ending

Company Name / Index     Dec99  Dec00 Dec01 Dec02 Dec03
------------------------ ------ ----- ----- ----- -----
HEMISPHERX BIOPHARMA INC 44.55 -52.20 -5.26 -52.67  6.10
S&P SMALLCAP 600 INDEX   12.40  11.80  6.54 -14.63 38.79
PEER GROUP              -23.18 -33.76 48.39 -45.76  5.33

                                 INDEXED RETURNS
                         Base    Years Ending
                         Period
Company Name / Index     Dec98  Dec99 Dec00  Dec01  Dec02  Dec03
------------------------ ------ ----- ------ -----  -----  ------
HEMISPHERX BIOPHARMA INC  100  144.55  69.09  65.45  30.98  32.87
S&P SMALLCAP 600 INDEX    100  112.40 125.67 133.88 114.30 158.63
PEER GROUP                100   76.82  50.88  75.51  40.95  43.14

Peer Group Companies
-----------------------------------------
AVI BIOPHARMA INC
IMMUNE RESPONSE CORP/DE
LA JOLLA PHARMACEUTICAL CO
MAXIM PHARMACEUTICALS INC


                             PRINCIPAL STOCKHOLDERS

         The  following  table sets forth as of April 26,  2004,  the number and
percentage of outstanding shares of common stock beneficially owned by:

o        Each  person,  individually  or as a group,  known to us to be
         deemed the  beneficial  owners of five  percent or more of our
         issued and outstanding common stock;
o        each of our directors and the Named Executives; and
o        all of our officers and directors as a group.

         This table is based upon information supplied by Schedules 13D and 13G,
if any,  filed with the  Securities  and Exchange  Commission,  and  information
obtained from our directors and named executives.  For purposes of this table, a
person  or group of  persons  is deemed to have  "beneficial  ownership"  of any
shares of common  stock  which such  person  has the right to acquire  within 60
days. For purposes of computing the  percentage of outstanding  shares of common
stock held by each person or group of persons  named in the table,  any security
which such person or persons  has or have the right to acquire  within such date
is deemed to be outstanding  but is not deemed to be outstanding for the purpose
of computing the percentage  ownership of any other person.  Except as indicated
in the  footnotes to this table and pursuant to  applicable  community  property
laws,  we  believe,  based on  information  supplied by such  persons,  that the
persons named in this table have sole voting and  investment  power with respect
to all shares  common stock which they  beneficially  own. As of April 26, 2004,
42,363,928 shares of our common stock were outstanding.  Unless otherwise noted,
the  address  of each of the  principal  stockholders  is care of us at One Penn
Center, 1617 JFK Boulevard, Philadelphia, Pennsylvania 19103.



Name and Address of      Shares Beneficially Owned   % Of Share Beneficially
Beneficial Owner                                     Owned
------------------------ -------------------------   ---------------------
William A. Carter, M.D.   5,760,028 (1)              12.1%

Robert E. Peterson          404,250 (2)                *

Ransom W. Etheridge          439,009(3)               1.0
2610 Potters Rd.
Virginia Beach, VA 23452

Richard C. Piani             196,747(4)                *
97 Rue Jeans-Jaures
Levaillois-Perret
France 92300


William M. Mitchell, M.D.    196,861(5)                *
Vanderbilt University
Department of Pathology
Medical Center North
21st and Garland
Nashville, TN 37232


Antoni Esteve                 347,446(6)               *
Laboratorios Del Dr. Esteve S.A.
AV. Mare de Deu de Montserat
Barcelona, 08041, Spain

David R. Strayer, M.D.        144,746(7)               *

Carol A. Smith                 41,791(8)               *

Iraj-Eqhbal Kiani              12,000(9)               *
Orange County Immune Institute
18800 Delaware Street
Huntingdon Beach, CA 92648

Mei-June Liao, Ph.D.               -                   -

Robert Hansen                      -                   -

All directors and executive officers as a
group (11 persons)             7,518,185            15.4
------------------------
* Less than 1%

(1)      Includes (i) an option to purchase  73,728  shares of common stock from
         Hemispherx  at an  exercise  price of $2.71 per share and  expiring  on
         August 8, 2004, (ii) Rule 701 Warrants to purchase  1,400,000 shares of
         common  stock at a price of $3.50 per  share,  originally  expiring  on
         September 30, 2002 was extended to September 30,2007; (iii) warrants to
         purchase  465,000  shares of common  stock at $1.75 per share issued in
         connection  with the 1995 Standby  Financing  Agreement and expiring on
         June 30, 2005; (iv) 340,000 common stock warrants  exercisable at $4.00
         per share and  originally  expiring on January 1, 2003 was  extended to
         January 1, 2008; (v) 170,000 common stock warrants exercisable at $5.00
         per share and  expiring  on January 2,  2005;(vi)  25,000  warrants  to
         purchase  common stock at $6.50 per share and expiring on September 17,
         2004;(vii)  25,000 warrants to purchase common stock at $8.00 per share
         and expiring on September 17, 2004;(viii)  100,000 warrants to purchase
         common  stock at $6.25 per share and  expiring  on April 8, 2004;  (ix)
         20,000 warrants to purchase common stock at $4.00 per share  originally
         expiring  January 1, 2003 was extended to January 1, 2008,  (x) 188,325
         common stock  warrants  exercisable  at $6.00 per share and expiring on
         February 22, 2006;  (xi) 188,325 common stock  warrants  exercisable at
         $9.00 per share and expiring on February 22, 2006 (xii) 300,000  common
         stock warrants  granted in 1998 that are exercisable at $6.00 per share
         and  expiring  on January 1, 2006  (xiii)  options to  purchase  10,000
         shares of common  stock at $4.03 per share and  expiring  on January 3,
         2011 (xiv) 500,000 warrants  exercisable  $2.00 per share in August 13,
         2007 (xv) 1,450,000 warrants exercisable at $2.20 per share expiring on
         September  9, 2008 and (x)  504,650  shares of common  stock.  Does not
         include  500,000  warrants  exercisable  at $2.00 per share expiring on
         August 13, 2007 that are not vested.

(2)      Includes  (i) 13,750  options to purchase  common  stock at an exercise
         price of $3.50 per share, expiring on January 7, 2007; (ii) warrants to
         purchase  50,000  shares of Common stock at an exercise  price of $3.50
         per  share,  expiring  on March 1, 2006;  (iii)  warrants  to  purchase
         100,000  shares of common  stock at $5.00 per share,  expiring on April
         14, 2006;  (iv) 30,000  warrants to purchase  common stock at $5.00 per
         share an expiring on February  28, 2009 (v) options to purchase  10,000
         shares at $4.03 per share that  expire on January 3, 2011 (vi)  200,000
         warrants exercised at $2.00 per share expiring on November 13, 2007 and
         (vii) 500 shares of common stock.

(3)      Includes  20,000  warrants to purchase common stock at $4.00 per share,
         originally  expiring on January 1, 2003 and was  extended to January 1,
         2008;  25,000  warrants  to purchase  common  stock at $6.50 per share;
         25,000  warrants  to  purchase  common  stock at $8.00 per  share,  all
         expiring on September 12, 2004; 100,000 warrants  exercisable $2.00 per
         share expiring on August 13, 2007; 200,000 stock options exercisable at
         $2.75 per share and  expiring on December 4, 2013 and 69,009  shares of
         common stock.

(4)      Includes  (i) 20,000  warrants  to purchase  common  stock at $4.00 per
         share; (ii) warrants to purchase 25,000 shares of common stock at $6.50
         per share;  (iii) 25,000 warrants to purchase common stock at $8.00 per
         share,  all  expiring  on  September  17,  2004;(vi)  100,000  warrants
         exercisable at $2.00 per share expiring on August 13, 2007,  (vi) 8,847
         shares of common stock owned by Mr. Piani (vi) 12,900  shares of common
         stock  owned  jointly by Mr. and Mrs.  Piani;  and (vii) 5000 shares of
         common stock owned by Mrs. Piani.

(5)      Includes  (I)  warrants to purchase  12,000  shares of common  stock at
         $6.00 per share,  expiring on August 25, 2008;  (ii) 25,000 warrants to
         purchase  common  stock at $6.50 per share;  (iii)  25,000  warrants to
         purchase  common stock at $8.00 per share all expiring on September 17,
         2004; (iv) 100,000 warrants  exercisable at $2.00 per share expiring in
         August 13, 2007 and 34,861 shares of common stock.

(6)      Consists of 347,446 shares of our common stock owned by Provesan S.A.,
         an affiliate of Laboratorios del Dr. Esteve S.A.  Dr.
         Antoni Esteve is a member of the executive committee and director
         of Scientific and Commercial Operations of Laboratorios
         del Dr. Esteve S.A.

(7)      Includes (i) stock options to purchase 20,000 shares of common stock at
         $3.50 per share; (ii) 50,000 warrants to purchase common stock at $4.00
         per share;  (iii) 10,000 stock options  exercisable  at $4.03 per share
         and  expiring on January 3, 2011;  50,000  warrants to purchase  common
         stock at $2.00 per share and  expiring  on August  13,  2007 and;  (iv)
         14,746 shares of common stock.

(8)      Consists of 5,000 warrants to purchase common stock at $4.00 per share
         expiring June 7, 2008; 6,791 stock options
         exercisable at $3.50 expiring January 22, 2007, 20,000 warrants
         exercisable at $2.00 per share expiring in August 13, 2007
         and options to purchase 10,000 shares of common stock at $ 4.03 per
         share expiring on January 3, 2011.

(9)      Consist of 12,000 warrants exercisable at $3.86 per share expiring on
         April 30, 2005.





                                 PROPOSAL NO. 2

                      RATIFICATION OF SELECTION OF AUDITORS

         The Board of Directors, upon the recommendation of the Audit Committee,
has appointed the firm of BDO Seidman, LLP as independent auditors of Hemispherx
for the fiscal year ending  December  31, 2004  subject to  ratification  by the
stockholders.  BDO Seidman, LLP has served as Hemispherx's  independent auditors
since June 2000.

         At the Annual Stockholder's Meeting on September 10, 2003, and pursuant
to the  recommendation  of  the  Audit  Committee  of the  Board  of  Directors,
stockholders  ratified  the  appointment  of the firm of BDO  Seidman,  LLP,  as
independent  accountants,  to audit the financial  statements of the Company for
the year end December 31, 2003.

         All audit and professional  services  provided by BDO Seidman,  LLP are
approved by the Audit Committee.  The total fees billed by BDO Seidman, LLP were
$178,429 in 2002 and $313,992 in 2003.  The following  table shows the aggregate
fees billed to us by BDO Seidman, LLP for professional  services rendered during
the year ended December 31, 2003.

-------------------- --------------------------------
                                   Amount ($)
-------------------- --------------------------------
-------------------- ----------------- --------------
Description of Fees         2002             2003
--------------------- ---------------- --------------
--------------------- ---------------- --------------
Audit Fees               $173,929         $264,917
--------------------- ---------------- --------------
--------------------- ---------------- --------------
Audit-Related Fees          4,500           43,580
--------------------- ---------------- --------------
--------------------- ---------------- --------------
Tax Fees                      -                 -
--------------------- --------------- ---------------
--------------------- --------------- ---------------
All Other Fees                -                 -
--------------------- --------------- ---------------
--------------------- --------------- ---------------

--------------------- --------------- ---------------
--------------------- --------------- ---------------
Total                     $178,429         $308,497
                          ========         ========
----------------------------------------- -----------


Audit Fees

         Represents fees for professional services provided for the audit of our
annual financial  statements and review of our financial  statements included in
our quarterly  reports and services in connection  with statutory and regulatory
filings.

Audit-Related Fees

         Represents  the  fees  for  assurance  and  related  services  that are
reasonably  related to the  performance  of the audit or review of our financial
statements,  including  those in 2002 and 2003 related to the acquisition of the
ISI business.

         The Audit Committee has determined that BDO Seidman, LLP's rendering of
these non-audit services is compatible with maintaining  auditors  independence.
The Board of Directors considers BDO Seidman,  LLP to be well qualified to serve
as  the  independent  public  accountants  of  the  Company.  If,  however,  the
stockholders  do not ratify the  appointment  of BDO Seidman,  LLP, the Board of
Directors  may,  but is not  required  to,  reconsider  the  appointment.  It is
anticipated  that a  representative  of BDO Seidman,  LLP will be present at the
Annual Meeting and will be available to respond to appropriate questions.

         The affirmative  vote of at least a majority of the shares  represented
and voting at the Annual  Meeting  at which a quorum is  present  (which  shares
voting affirmatively also constitute at least a majority of the required quorum)
is necessary for approval of Proposal No. 2.

     THE BOARD OF DIRECTORS  DEEMS PROPOSAL NO. 2 TO BE IN THE BEST INTERESTS OF
HEMISPHERX AND ITS STOCKHOLDERS AND RECOMMENDS A VOTE "FOR" APPROVAL THEREOF.

                                 PROPOSAL NO. 3

   APPROVAL OF THE ISSUANCE OF 13,468,793 SHARES OF COMMON STOCK ISSUABLE UPON
    EXERCISE OF CERTAIN WARRANTS AND UPON CONVERSION OF CERTAIN OUTSTANDING
  DEBENTURES AND DEBENTURES ISSUABLE UPON EXERCISE OF CERTAIN RIGHTS TO COMPLY
                      WITH AMEX COMPANY GUIDE SECTION 713

As described below, in three transactions  between July 10, 2003 and January 26,
2004,  we  issued  convertible   debentures,   rights  to  purchase  convertible
debentures,  warrants and common stock in private  transactions  with accredited
investors.  Section 713 of the American  Stock Exchange  ("AMEX")  Company Guide
provides that we must obtain  stockholder  approval before issuance,  at a price
per share below market value,  of common stock, or securities  convertible  into
common  stock,  equal  to 20% or more of our  outstanding  common  stock.  Taken
separately, the three transactions do not trigger Section 713. However, the AMEX
has taken the position that the three transactions  should be aggregated and, as
such,  stockholder  approval is required for exercise of all of the warrants and
conversion of some of the Debentures.

To assure that we are in  compliance  with  Company  Guide  Section  713, we are
requesting  your  approval  of  the  issuance  of  13,468,793  shares  (includes
2,798,097 anti-dilution shares) upon conversion of all of the warrants, and upon
conversion  of all of  the  outstanding  debentures  and  all of the  debentures
issuable upon exercise of rights described below.

Description of the transactions.
-------------------------------

On July 10, 2003, we issued an aggregate of $5,426,000 in principal amount of 6%
Senior  Convertible  Debentures due July 31, 2005 (the "July Debentures") and an
aggregate  of 507,103  Warrants  (the "July 2008  Warrants")  to two  accredited
investors,  in  a  private  placement  for  aggregate  anticipated  proceeds  of
$4,650,000.  Pursuant  to the terms of the July  Debentures,  $1,550,000  of the
proceeds  from the sale of the July  Debentures  were to have been held back and
released to us if, and only if, we acquired the facility of Interferon Sciences,
Inc. ("ISI") with in a set timeframe. These funds were released to us in October
2003  although  we had not  acquired  ISI's  facility  at that  time.  The  July
Debentures  mature on July 31, 2005 and bear  interest at 6% per annum,  payable
quarterly in cash or,  subject to  satisfaction  of certain  conditions,  common
stock. Any shares of common stock issued to the investors as payment of interest
shall be valued at 95% of the average  closing  price of the common stock during
the five consecutive  business days ending on the third business day immediately
preceding the applicable interest payment date.

The July  Debentures are  convertible at the option of the investors at any time
through  July 31, 2005 into shares of our common  stock.  The  conversion  price
under the July Debentures was fixed at $2.14 per share;  however, as part of the
debenture placement closed on October 29, 2003 (see below), the conversion price
under the July Debentures was lowered to $1.89 per share.  The conversion  price
is subject to adjustment  for  anti-dilution  protection  for issuance of common
stock or securities  convertible  or  exchangeable  into common stock at a price
less than the conversion price then in effect. In addition, in the event that we
do not pay the redemption  price at maturity,  the Debenture  holders,  at their
option,  may convert the  balance due at the lower of (a) the  conversion  price
then in effect and (b) 95% of the lowest  closing sale price of our common stock
during the three trading days ending on and including the conversion date.

The July 2008 Warrants, as amended,  received by the investors are to acquire at
any time  commencing  on July 26, 2004 through  January 31, 2009 an aggregate of
507,102 shares of common stock at a price of $2.46 per share.  On July 10, 2004,
the exercise  price of these July 2008  Warrants will reset to the lesser of the
exercise price then in effect or a price equal to the average of the daily price
of the common stock between July 11, 2003 and July 9, 2004 (but in no event less
than $2.14 per share).  The exercise  price (and the reset price) under the July
2008  Warrants  also  is  subject  to  similar   adjustments  for  anti-dilution
protection.

On October 29, 2003, we issued an aggregate of $4,142,357 in principal amount of
6% Senior Convertible Debentures due October 31, 2005 (the "October Debentures")
and an aggregate of 410,134  Warrants (the "October 2008 Warrants") in a private
placement for aggregate  anticipated  gross proceeds of $3,550,000.  Pursuant to
the terms of the October Debentures, $1,550,000 of the proceeds from the sale of
the  October  Debentures  have been held back and will be released to us if, and
only if, we  acquire  ISI's  facility  within 90 days of  January  26,  2004 and
provide  a  mortgage  on the  facility  as  further  security  for  the  October
Debentures. In March 2004, we acquired the facility and we are in the process of
mortgaging the facility to the Debenture holders.  The October Debentures mature
on October 31, 2005 and bear interest at 6% per annum, payable quarterly in cash
or, subject to satisfaction of certain  conditions,  common stock. Any shares of
common stock issued to the  investors as payment of interest  shall be valued at
95% of the average closing price of the common stock during the five consecutive
business  days  ending on the  third  business  day  immediately  preceding  the
applicable interest payment date.

Upon completing the sale of the October  Debentures,  we received  $3,275,000 in
net proceeds consisting of $1,725,000 from the October Debentures and $1,550,000
that had been withheld from the July Debentures.  As noted above,  $1,550,000 of
the  proceeds  from the  October  Debentures  have been held  back  pending  our
mortgaging of the ISI facility to the Debenture  holders.  We are in the process
of providing this mortgage.

The October  Debentures  are  convertible  at the option of the investors at any
time through  October 31, 2005 into shares of our common stock.  The  conversion
price  under the  October  Debentures  is fixed at $2.02 per  share,  subject to
adjustment  for  anti-dilution  protection  for  issuance  of  common  stock  or
securities  convertible or  exchangeable  into common stock at a price less than
the conversion  price then in effect.  In addition,  in the event that we do not
pay the redemption price at maturity,  the Debenture  holders,  at their option,
may convert the  balance  due at the lower of (a) the  conversion  price then in
effect and (b) 95% of the lowest  closing  sale price of our common stock during
the three trading days ending on and including the conversion date.

The October 2008 Warrants, as amended,  received by the investors are to acquire
at any time  commencing  on July 26, 2004 through April 30, 2009 an aggregate of
410,134  shares of common  stock at a price of $2.32 per share.  On October  29,
2004, the exercise price of these October 2008 Warrants will reset to the lesser
of the  exercise  price  then in effect or a price  equal to the  average of the
daily price of the common  stock  between  October 29, 2003 and October 27, 2004
(but in no event less than $2.19 per share).  The exercise  price (and the reset
price) under the October 2008  Warrants  also is subject to similar  adjustments
for anti-dilution protection.

On January 26, 2004,  we issued:  (i) an aggregate  of  $4,000,000  in principal
amount of 6% Senior  Convertible  Debentures  due January 31, 2006 (the "January
2004 Debentures");  (ii) an aggregate of 790,514 warrants (the "2009 Warrants");
(iii) 158,103  shares of common stock;  and (iv)  Additional  Investment  Rights
("AIR") to purchase up to an additional  $2,000,000  principal amount of January
2004 Debentures  commencing in six months,  in a private placement for aggregate
net proceeds of $3,695,000.  The January 2004  Debentures  mature on January 31,
2006 and bear interest at 6% per annum, payable quarterly in cash or, subject to
satisfaction  of certain  conditions,  common stock.  Any shares of common stock
issued to the  investors  as payment of  interest  shall be valued at 95% of the
average closing price of the common stock during the five  consecutive  business
days ending on the third  business  day  immediately  preceding  the  applicable
interest payment date.  Commencing six months after issuance, we are required to
start  repaying  the then  outstanding  principal  amount under the January 2004
Debentures in monthly  installments  amortized over 18 months in cash or, at our
option,  in shares of common  stock.  Any shares of common  stock  issued to the
investors as installment  payments shall be valued at 95% of the average closing
price of the common stock during the 10-day  trading  period  commencing  on and
including  the  eleventh  trading day  immediately  preceding  the date that the
installment is due.

The January 2004  Debentures  are  convertible at the option of the investors at
any time  through  January  31,  2006  into  shares  of our  common  stock.  The
conversion  price under the January 2004 Debentures is fixed at $2.53 per share,
subject to adjustment for anti-dilution  protection for issuance of common stock
or securities convertible or exchangeable into common stock at a price less than
the conversion  price then in effect.  In addition,  in the event that we do not
pay the redemption price at maturity,  the Debenture  holders,  at their option,
may convert the  balance  due at the lower of (a) the  conversion  price then in
effect and (b) 95% of the lowest  closing  sale price of our common stock during
the three trading days ending on and including the conversion date.

There are two classes of July 2009 warrants  received by the Investors:  Class A
and Class B. The Class A  warrants  are to acquire  any time from July 26,  2004
through July 26, 2009 an aggregate of up to 395,257  shares of common stock at a
price of $3.29 per share. The Class B warrants are to acquire any time from July
26, 2004 through  July 26, 2009 an  aggregate of up to 395,257  shares of common
stock at a price of $5.06 per share.  On January 27, 2005, the exercise price of
these July 2009  Class A and Class B Warrants  will reset to the lesser of their
respective  exercise price then in effect or a price equal to the average of the
daily price of the common  stock  between  January 27, 2004 and January 26, 2005
(but in no event less than  $2.58 per share with  regard to the Class A warrants
and $3.54 per share with regard to the Class B  warrants).  The  exercise  price
(and the reset  price) under the July 2009  Warrants  also is subject to similar
adjustments for anti-dilution protection.

The above  mentioned  AIR  grant the  investors  the right to  acquire  up to an
additional $2,000,000 principal amount of January 2004 Debentures from us. These
Debentures  are  identical  to the  January  2004  Debentures  except  that  the
conversion price is $2.58.  The AIR are exercisable  commencing on July 26, 2004
(the  "Trigger"  date) for a period of 90 days from the Trigger  Date or 90 days
from the date which the registration  statement  registering the shares issuable
upon the conversion of the January 2004  Debentures to be issued pursuant to the
AIR is declared effective, whichever is longer.

Pursuant to the terms and conditions of the July Debentures,  October Debentures
and January 2004 Debentures  (collectively,  the "Debentures"),  we have pledged
all of our assets, other than our intellectual  property, as collateral,  and we
are  subject  to comply  with  certain  financial  and  negative  covenants.  In
addition,  we have paid $1,300,000 into the Debenture cash collateral account as
required by the terms of the Debentures.  The cash collateral  account  provides
additional security for repayment of the Debentures in the event of default.

We entered into Registration  Rights Agreements with the investors in connection
with  the  issuance  of (i) the  Debentures  (including  any  Debentures  issued
pursuant to the AIR); (ii) the July 2008, October 2008 and January 2009 Warrants
(collectively,  the  "Warrants");  and (iii) the shares  issued in January 2004.
Pursuant to the Registration  Rights  Agreements we have registered on behalf of
the  investors  the shares issued to them in January 2004 and 135% of the shares
issuable upon  conversion of the Debentures  (including  any  Debentures  issued
pursuant to the AIR) and upon exercise of the Warrants.  If , subject to certain
exceptions,  sales of all shares so  registered  cannot be made  pursuant to the
registration statements,  then we will be required to pay to the investors their
pro rata share of $3,635 for each day the above condition exists.

By agreement  with  Cardinal  Securities,  LLC, for general  financial  advisory
services and in conjunction  with the private  debenture  placements in July and
October 2003 and in January 2004, we paid Cardinal Securities, LLC an investment
banking fee equal to 7% of the investments made by the two Debenture holders and
issued to Cardinal the following  common stock  purchase  warrants:  (i) 112,500
exercisable at $2.57 per share; (ii) 87,500  exercisable at $2.42 per share; and
(iii) 100,000  exercisable at $3.04 per share. The $2.57 warrants expire on July
10, 2008, the $2.42  warrants  expire on October 30, 2008 and the $3.04 warrants
expire on  January 5, 2009.  By  agreement  with  Cardinal,  we have  registered
300,000 of the shares  issuable upon exercise of these  warrants for public sale
and agreed to register the balance.  We are seeking  approval of the issuance of
the shares upon exercise of these warrants too.

As of the record date, the investors had converted  $11,902,610 of debt from the
March,  July and October  Debentures into 7,073,234  shares of our common stock.
The March Debentures have been fully converted.  The remaining principal balance
on the Debentures is  convertible  into shares of our stock at the option of the
investors at any time, through their respective maturity dates.

We have used and continue to use the net proceeds from these  private  offerings
for operating purposes.

Effects of issuance of the shares

A  significant  number  of  shares  will  be  issuable  upon  conversion  of the
Debentures and exercise of the Warrants. To the extent that a significant number
of these shares are issued, there will be a substantial pro rata dilution to our
current stockholders. In addition, because these shares have been registered for
public sale, such sales,  or the  anticipation of the possibility of such sales,
represents  an overhang on the market and could  depress the market price of our
common stock.

However,  if issuance of the these  shares is not approved by  stockholders,  we
will be unable to issue shares upon exercise of approximately 2,707,751 warrants
and we will be unable to issue shares upon conversion of the Debentures issuable
upon exercise of the AIR.  Depending upon the amount and timing of conversion of
the  outstanding  Debentures,  we also may be required  to pay  interest in cash
rather than shares.

Pursuant to the terms of the  Warrants,  if  stockholders  do not  approve  this
resolutions, any time the Warrant holder presents a notice of exercise, we would
be  required  to pay  within  two  business  days an amount in cash equal to the
product of (X) the number of shares of common  stock  which  could not be issued
multiplied  by (Y) the excess of (1) the average of the  closing  sale prices of
the common stock on each of the five  trading  days ending on the third  trading
day immediately  preceding the date that the Warrants become  unexercisable as a
result of the  stockholders  failure to  approve  this  resolution  over (2) the
warrant exercise price then in effect.

Pursuant to the terms of the  Debentures  issuable  upon exercise of the AIR, if
stockholders  do not approve this  resolutions,  any time the  Debenture  holder
presents a notice of conversion, we would be required to pay within two business
days an amount in cash equal to the number of shares of common stock which could
not be issued multiplied by (Y) the average of the weighted average price of the
common stock on each of the five  trading  days ending on the third  trading day
immediately preceding the date of delivery of such conversion notice.

     THE BOARD OF DIRECTORS  DEEMS PROPOSAL NO. 3 TO BE IN THE BEST INTERESTS OF
HEMISPHERX AND ITS STOCKHOLDERS AND RECOMMENDS A VOTE "FOR" APPROVAL THEREOF.


                                 PROPOSAL NO. 4

              APPROVAL OF THE HEMISPHERx 2004 EQUITY INCENTIVE PLAN

         The Company is submitting  the  Hemispherx  2004 Equity  Incentive Plan
(the "Equity  Incentive  Plan") to the  stockholders  for approval at the annual
meeting. The Equity Incentive Plan is intended to attract and retain individuals
of experience and ability, to provide incentive to employees,  consultants,  and
non-employee  directors  of the  Company,  to  encourage  employee  and director
proprietary  interests in the Company,  and to encourage  employees to remain in
the employ of the Company.  The Equity  Incentive Plan is  conditioned  upon the
stockholders'  approval.  The purposes of obtaining stockholder approval include
qualifying  the Equity  Incentive  Plan  under the  Internal  Revenue  Code (the
"Code") for the granting of incentive  stock options;  meeting the  requirements
for  tax-deductibility of certain compensation items under Section 162(m) of the
Code; and meeting the  requirements of AMEX  applicable to the Equity  Incentive
Plan.

         The following  general  description  of certain  features of the Equity
Incentive Plan is qualified in its entirety by reference to the Equity Incentive
Plan, which is attached as Appendix A. Capitalized  terms not otherwise  defined
herein have the meanings ascribed to them in the Equity Incentive Plan.

         The Board of Directors  adopted the Equity Incentive Plan effective May
1, 2004,  subject to the  approval  of the  Company's  stockholders.  The Equity
Incentive  Plan  authorizes  the  grant of  non-qualified  and  incentive  stock
options,  stock appreciation rights,  restricted stock and other stock awards. A
maximum of 8,000,000  shares of common stock is reserved for potential  issuance
pursuant to awards under the Equity  Incentive Plan.  Unless sooner  terminated,
the Equity  Incentive Plan will continue in effect for a period of 10 years from
its effective date.

         The Equity  Incentive Plan is  administered  by the Board of Directors.
The Equity Incentive Plan provides for awards to be made to such officers, other
key employees,  non-employee directors,  consultants and advisors of the Company
and its subsidiaries as the Board may select.  No awards have been granted under
the Equity Incentive Plan.

         Stock  options   awarded  under  the  Equity   Incentive  Plan  may  be
exercisable  at such times (not later than 10 years after the date of grant) and
at such  exercise  prices (not less than fair market value at the date of grant)
as the  Board  may  determine.  The  Board may  provide  for  options  to become
immediately  exercisable  upon a "change  in  control,"  which is defined in the
Equity  Incentive  Plan to  occur  upon  any of the  following  events:  (a) the
acquisition by any person or group,  as beneficial  owner, of 20% or more of the
outstanding  shares or the voting  power of the  outstanding  securities  of the
Company;  (b)  either a  majority  of the  directors  of  Company  at the annual
stockholders meeting has been nominated other than by or at the direction of the
incumbent directors of the Board, or the incumbent directors cease to constitute
a majority of the  Company's  Board;  (c) the Company's  stockholders  approve a
merger or other business  combination  pursuant to which the outstanding  common
stock of the Company no longer  represents  more than 50% of the combined entity
after the transaction; (d) the Company's shareholders approve a plan of complete
liquidation or an agreement for the sale or disposition of all or  substantially
all of the Company's assets;  or (e) any other event or circumstance  determined
by the  Company's  Board to affect  control of the  Company  and  designated  by
resolution of the Board as a change of control.

         The exercise price of an option may be paid with cash, common stock, or
such other  consideration  as the Board may  specify.  No options may be granted
under the Equity  Incentive  Plan after the tenth  anniversary  of its effective
date. Unless the Board determines  otherwise,  options will be transferable only
by will or the laws of descent and distribution.

         Stock  appreciation  rights awarded under the Equity Incentive Plan may
be granted as related rights,  either in connection with and at the same time as
an option is granted, or by amendment of an outstanding  non-qualified option. A
related stock  appreciation  right may be granted with respect to all or some of
the shares  covered by the related  option.  Related stock  appreciation  rights
generally  become  exercisable  at the same times as the related  options become
exercisable,  but may be limited so as to become  exercisable  only upon certain
events,  such as a change in  control.  Upon  exercise of a related  right,  the
grantee would receive,  in lieu of purchasing stock,  either stock or cash equal
to the  difference  between the fair market value on the date of exercise of the
underlying shares of common stock subject to the related option and the exercise
price of the option. Stock appreciation rights may also be granted independently
of any option,  to become  exercisable at such times as the Board may determine.
Upon exercise of such a right,  the grantee  would receive  either stock or cash
equal to the difference between the fair market value on the date of exercise of
the shares of common stock subject to the right and the fair market value of the
shares on the date of grant of the right.

         Restricted stock awarded under the Equity Incentive Plan may be granted
on such terms and  conditions as the Board may determine,  including  provisions
that govern the lapse of  restrictions  and voting  dividend,  distribution  and
other  shareholder  rights with respect to the restricted stock. If a grantee of
restricted stock terminates service with the Company for any reason, the grantee
will forfeit to the Company any restricted stock on which the restrictions  have
not lapsed or been removed on or before the date of termination of service.

         Other  stock  awards  under the Equity  Incentive  Plan may provide for
common stock to be issued to grantees in exchange for consideration specified by
the Board  that is either  the  grantee's  cash or other  direct  payment to the
Company or the grantee's  past services  rendered to the Company or a subsidiary
on or before issuance.

                 The following is a brief summary of certain of the U.S. federal
income tax consequences of certain  transactions under the Equity Incentive Plan
based on federal  income tax laws in effect on  January  1, 2004.  This  summary
applies to the Equity Incentive Plan as normally operated and is not intended to
provide or supplement  tax advice to eligible  employees.  The summary  contains
general   statements   based  on  current  U.S.  federal  income  tax  statutes,
regulations and currently available interpretations thereof. This summary is not
intended to be  exhaustive  and does not  describe  state,  local or foreign tax
consequences or the effect, if any, of gift, estate and inheritance taxes.

         Grants of options or stock  appreciation  rights are not taxable income
to the grantees or deductible for tax purposes by the Company at the time of the
grant. In the case of non-qualified  stock options,  a grantee will be deemed to
receive ordinary income upon exercise of the stock option,  and the Company will
be entitled to a  corresponding  deduction,  in an amount equal to the amount by
which  the  fair  market  value of the  common  stock  purchased  on the date of
exercise  exceeds the exercise price.  The exercise of an incentive stock option
will not be taxable to the grantee or deductible by the Company,  but the amount
of any income deemed to be received by a grantee due to premature disposition of
common stock  acquired upon the exercise of an incentive  stock option will be a
deductible  expense  of the  Company  for tax  purposes.  In the  case of  stock
appreciation  rights,  a grantee will be deemed to receive  ordinary income upon
exercise  of the right,  and the Company  will be  entitled  to a  corresponding
deduction, in an amount equal to the cash or fair market value of shares payable
to the grantee.  Grantees of restricted  stock awards  generally  will recognize
ordinary  income in an amount  equal to the fair  market  value of the shares of
common  stock  granted to them at the time that the  restrictions  on the shares
lapse and the shares  become  transferable.  At that time,  the Company  will be
entitled to a corresponding  deduction equal to the amounts recognized as income
by the grantees in the year in which the amounts are  included in the  grantees'
income.  Grantees of stock issued  pursuant to other stock awards will generally
receive  ordinary  income,  and the Company will be entitled to a  corresponding
deduction,  in an amount  equal to the amount by which the fair market  value of
the common  stock on the date of issuance  exceeds the  grantee's  cash or other
payment to the Company, if any.

         Section  162(m)  of  the  Code  generally  disallows  a  publicly  held
corporation's tax deduction for certain compensation in excess of $1 million per
year  paid to each of the  five  most  highly  compensated  executive  officers,
exclusive of compensation that is "performance-based."  The Company has designed
the Equity  Incentive  Plan in a manner  that is intended to qualify the options
and any stock  appreciation  rights  granted under the Equity  Incentive Plan as
performance-based  compensation  that  will  not be  subject  to  the  deduction
limitation of Section 162(m). Any grant of restricted stock or other stock award
could  (but  is not  required  to) be  designed  to  avoid  any  such  deduction
limitation.

         The Board has the general power to amend the Equity  Incentive  Plan in
any  respect.  However,  if  the  Equity  Incentive  Plan  is  approved  by  the
stockholders at the annual meeting,  the Board may not, without further approval
of the  Company's  stockholders,  amend the Plan so as to increase the aggregate
number of shares of common stock that may be issued  under the Equity  Incentive
Plan,  modify  the  requirements  as to  eligibility  to receive  awards,  or to
increase  materially the benefits  accruing to  participants.  In addition,  the
Board is permitted to modify, extend or renew outstanding stock options or stock
appreciation  rights,  and to  authorize  the  granting  of new options or stock
appreciation  rights in substitution for existing  options and rights.  However,
existing options or rights may not be repriced, directly or indirectly, so as to
provide for modified or new options or rights with an exercise  price lower than
the  exercise  price  provided  for the  outstanding  stock  options  and  stock
appreciation  rights.  The Board is also  authorized to accelerate  the lapse of
restrictions on restricted  stock awards or to remove any or all restrictions at
any time.

     THE BOARD OF DIRECTORS  DEEMS PROPOSAL NO. 4 TO BE IN THE BEST INTERESTS OF
HEMISPHERx  AND ITS  STOCKHOLDERS  AND RECOMMENDS A VOTE FOR THE APPROVAL OF THE
HEMISPHERx 2004 EQUITY INCENTIVE PLAN


                                     GENERAL

     Unless  contrary  instructions  are  indicated on the proxy,  all shares of
     common  stock  represented  by  valid  proxies  received  pursuant  to this
     solicitation  (and not revoked before they are voted) will be voted FOR the
     election of all directors nominated and FOR Proposals No. 2, 3 and 4.

     The Board of Directors knows of no business other than that set forth above
     to be transacted at the meeting,  but if other matters  requiring a vote of
     the  stockholders  arise,  the persons  designated as proxies will vote the
     shares of common stock  represented by the proxies in accordance with their
     judgment on such matters. If a stockholder  specifies a different choice on
     the proxy,  his or her shares of common  stock will be voted in  accordance
     with the specification so made.

     IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY.  WE URGE YOU TO FILL IN,
     SIGN AND  RETURN THE  ACCOMPANYING  FORM OF PROXY IN THE  PREPAID  ENVELOPE
     PROVIDED, NO MATTER HOW LARGE OR SMALL YOUR HOLDINGS MAY BE.

                                     By Order of the Board of Directors,
                                     Ransom W. Etheridge, Secretary




     Philadelphia, Pennsylvania
     May   , 2004