UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 8-K/A


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                        Date of Report (Date of earliest
                           event reported) October 7,
                             2005 ( October 6, 2005)

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
               (state or other juris- (Commission (I.R.S. Employer
           diction of incorporation) File Number) (Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080

                                                                       
          (Former name or former address, if changed since last report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12) [ ] Pre-commencement  communications pursuant to Rule 14d-2(b) under
the Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))








Section 1 - Registrant's Business and Operations

Item 1.01 Entry into a Material Definitive Agreement.

We entered into a more formal agreement with regard to the transactions reported
in our original Current Report on Form 8-K.

Effective  October 6, 2005, we amended our outstanding  debentures due to mature
on October 31, 2005 and January 31, 2006 as follows:

1.       The maturity date was extended to June 30, 2007 and
2.       the interest rate was increased from 6% per annum to 7% per annum.

We agreed to issue to the debenture  holders common stock  purchase  warrants to
purchase,  in the aggregate,  225,000 shares of our common stock for a period of
four years at an exercise price of $2.50 per share.

We also agreed to register on their behalf 135% of the shares  issuable upon the
payment of interest on the debentures (giving effect to the revised terms of the
debentures) and exercise of the warrants.

         For a  complete  description  of this  transaction,  see the  Amendment
Agreement,  forms of amended Convertible  Debenture and form of Warrant filed as
Exhibits 10.1, 10.2, 10.3, 10.4 and 10.5 to this amended Report and incorporated
herein by reference.

Item 9.01 Financial Statements and Exhibits.

(c) Exhibits.  The following exhibits are filed herewith:

10.1 Amendment  Agreement,  effective  October 6, 2005, by and among the Company
and debenture holders.

10.2 Form of Series A amended 7% Convertible  Debenture of the  Company(amending
Debenture due October 31, 2005).

10.3 Form of Series B amended 7% Convertible  Debenture of the Company (amending
Debenture issued on January 26, 2004 and due January 31, 2006).

10.4 Form of Series C amended 7% Convertible Debentures of the Company (amending
Debenture issued on July 13, 2004 and due January 31, 2006).

10.5     Form of Warrant for Common Stock of the Company.







                                                              SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                              HEMISPHERX BIOPHARMA, INC.


October 28, 2005             By:  /s/ William A. CArter
                                             --------------------------------
                                             William A. Carter M.D., President