Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) a leader in the development of Antibody Radiation Conjugates (ARCs) and other targeted radiotherapies announced that an abstract detailing the first ever preclinical data from the combination of menin inhibitors with Actinium's ARC Actimab-A in acute myeloid leukemia (AML) models was presented at the 2024 European Hematology Association (EHA) Congress held June 13 – 16, 2024, in Madrid, Spain.
Actinium studied Actimab-A in combination with the leading menin inhibitors, revumenib (Syndax Pharmaceuticals, Inc.) and ziftomenib (Kura Oncology, Inc.), which are being developed for patients with KMT2A rearrangements and NMP1 mutations, which are present in approximately 10% and 30% of AML patients, respectively.
Acute Myeloid Leukemia Market size is estimated at USD 1.83 billion in 2024, and is expected to reach USD 2.97 billion by 2029, growing at a CAGR of 10.15% during the forecast period (2024-2029). As per the report, the key factors propelling the growth of this market are the high incidence and prevalence of acute myeloid leukemia, advancements in pharmacology and molecular biology to promote drug development and increasing investments in research and development by pharmaceutical companies. According to the American Cancer Society, it is estimated that there will be 60,650 new leukemia cancer cases, of which 24,000 are expected to die in 2022 in the US. In addition, according to the same source, 20,050 new cases of acute myeloid leukemia (AML) are estimated in 2022 in the US. It will lead to increased adoption of AML therapies. The rising prevalence of AML in developed countries such as the US is expected to drive this market's growth. Furthermore, with the rising investment in research and development, there is an increasing number of clinical trials conducted to demonstrate the effectiveness of the drugs. It is expected to drive the market over the forecast period.
Sandesh Seth, Actinium's Chairman and CEO, said, "Combining with menin inhibitors is an exciting expansion of the already broad potential of Actimab-A in AML. Across single agent and combination studies, Actimab-A has produced high rates of response, MRD negativity and improved survival in high-risk, relapsed and refractory patients including those with a TP53 mutation and venetoclax failures. The broad expression of CD33 in AML coupled with the potency of Actinium-225 make Actimab-A an ideal agent for treating radiation sensitive AML. We are encouraged by this highly promising initial data and the synergistic potential of Actimab-A with menin inhibitors, which has broad potential across the AML treatment continuum including frontline, maintenance and relapsed/refractory settings. We are eager to continue to study this combination and generate additional data that could support advancing into clinical studies of Actimab-A with menin inhibitors."
Menin inhibitors are a class of drug candidates being developed for patients with AML that have a rearrangement of the KMT2A gene, previously known as the mixed-lineage leukemia (MLL) or mutation of the NPM1 gene. There are multiple menin inhibitors in development for these patients with revumenib (Syndax Pharmaceuticals, Inc.) being most advanced having a PDUFA data of September 2024 and ziftomenib (Kura Oncology, Inc.) enrolling patients in a registration Phase 2 trial. Multiple menin inhibitors are being studied in Phase 1 clinical trials by companies including Johnson & Johnson, Sumitomo Pharma Co., Ltd., Hutchmed, Biomea Fusion, Inc. and BioNova Pharmaceuticals Pvt Ltd.
If we look at the Actinium Pharmaceuticals (ATNM) Stock Forecast & Price Target, based on 5 Wall Street analysts offering 12 month price targets for Actinium Pharmaceuticals in the last 3 months, the average price target is $29.40 with a high forecast of $50.00 and a low forecast of $16.00. The average price target represents a 270.74% change from the last price of $7.93.
As always, conduct your own due diligence and follow traders vigilance. Other biotech stocks to keep on top of radar include Eli Lilly & Co. (NYSE: LLY): An FDA panel voted unanimously in favor of the company’s donanemab drug, which would be used to treat Alzheimer’s. Lexaria Bioscience (NASDAQ: LEXX): Its drug delivery system makes treatments easier to take and drugs more effective. Novo Nordisk (NYSE: NVO): The company’s running its manufacturing operations 24 hours a day to meet demand for Wegovy. Bristol-Myers Squibb (BMY) offers a powerful oncological portfolio. Neurocrine’s (NBIX) neurology specialty could facilitate big shareholder gains. Amgen (AMGN) could start marching into the lead in the immunology category.
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Sources:
https://finance.yahoo.com/news/actinium-presents-first-ever-data-120000224.html
https://www.tipranks.com/stocks/atnm/forecast#google_vignette
https://www.morningstar.com/news/globe-newswire/9154521/acute-myeloid-leukemia-market-size-expected-to-reach-297-billion-by-2029-as-clinical-trials-increase
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