H&Q HEALTHCARE INVESTORS [GRAPHIC] ANNUAL REPORT 2002 To our Shareholders: At fiscal year-end on September 30, 2002, the net asset value of your Fund was $18.16 per share. Performance data for the fiscal year and the quarter ended September 30, 2002, compared to the indices, are as follows: QUARTER ENDED FISCAL YEAR 9/30/02 ----------- ------- Net Asset Value -23.5% -9.3% AMEX Biotech Index -29.0% -8.3% Dow Jones Industrial Average -14.2% -17.9% NASDAQ Industrials -14.2% -21.8% Russell 2000 -10.5% -21.7% The final quarter of your Fund's fiscal year was one of the worst on record for the general market averages. Your Fund's decline was significant, but overall less severe on a relative basis. We believe we are in a period of no widely held consensus. Some may believe a return to recession is highly likely in an economy of excess capacity worldwide, nervous and indebted consumers, a possible real estate bubble, war risk, and potential deflation, an outlook not fully reflected in security prices. Others look at the correction in equity prices of the last few years, including those of companies leading the world's strongest economy, no meaningful inflation, and historically low interest rates and wonder why stocks shouldn't be bought. They may believe the U.S. economy has always rebounded in the past and will again. We espouse neither of these extremes, but we do believe moderation of this polarization of sentiment may be required to set the foundation of the next bull market. We are encouraged, however, that within the context of the overall market, a positive consensus does seem to be developing toward healthcare companies. Through all the recent turmoil, these companies have, in our judgment, continued to invent and develop new innovative products with exciting potential to enhance diagnosis and therapy. The number and therapeutic potential of products heading for FDA approval in the next year or so is inspiring. In our view, many of the 1 sponsoring companies have reasonable business plans (unlike some of the "dotcoms" of a few years ago). Further, we believe that there are no telecom-like over capacity issues here. In our view, these new products, intended to improve the human condition, will largely generate their own demand. We believe that recognition of these developments is reflected in the better relative performance of the sector in the third quarter of 2002 and is likely to continue. We are cautiously adding to or initiating positions in the stocks of the more attractive of these companies, which may, over time, reduce our cash position. Many large investment firms have announced significant layoffs and staff reductions. In the first quarter, we made a significant addition of a very experienced staff member as we continue to build for the future. As a private company owned by its management, Hambrecht & Quist Capital Management LLC, your Fund's adviser, has the ability to take a longer-term view and build its most important asset, its people. The corporate governance, accounting and security analysts controversies have clearly had depressing affects on stock prices. We wonder if good analysis might have uncovered a lot of these controversies earlier; perhaps not as to the accounting issues, which, in our view are largely rooted in the tax code. As portfolio managers, we have long believed that one of our foremost duties was the analysis of analysts, including our own, and especially those who work for sell-side brokers and investment bankers. Perhaps the recent long bull market made investors feel "entitled" to stock profits, and able to blame others for their losses. We do not believe we are "entitled" to anything more than the opportunity to use our energy and talent to find investments likely to yield long-term profit growth. /s/ Alan G. Carr /s/ Daniel R. Omstead Alan G. Carr Daniel R. Omstead President Emeritus President 2 H&Q HEALTHCARE INVESTORS LARGEST HOLDINGS AS OF SEPTEMBER 30, 2002 % OF NET ASSETS --------------- Gilead Sciences 5.91% Transkaryotic Therapies 3.55% Martek Biosciences 2.99% Celgene 2.86% CV Therapeutics 2.70% Triad Therapeutics (Restricted) 2.13% CardioNet (Restricted) 1.98% IDEXX Laboratories 1.94% Teva Pharmaceutical Industries 1.94% Telik 1.89% H&Q HEALTHCARE INVESTORS SIGNIFICANT PORTFOLIO TRANSACTIONS QUARTER ENDED SEPTEMBER 30, 2002 UNITS HELD UNITS HELD PURCHASES 6/30/02 9/30/02 --------- ------- ------- Adolor 232,980 311,300 Corixa 246,389 441,471 Exelixis 467,100 732,600 IVAX 154,800 214,800 Lexicon Genetics 78,500 111,500 WebMD 403,500 454,500 Zyomyx (Restricted) Series E 0 600,000 SALES ----- ATS Medical 381,818 0 Bioject Medical Technologies 130,900 0 Curis 92,500 0 3 PORTFOLIO AS OF SEPTEMBER 30, 2002 [CHART] TOTAL VENTURE DIFFERENCE ----- ------- ---------- AGRI/ENVIRONMENTAL 1.90% 1.80% 0.10% BIOTECHNOLOGY 46.60% 11.40% 35.20% CROs 0.40% 0.00% 0.40% DIAGNOSTICS 7.50% 4.00% 3.50% HEALTHCARE INFORMATION SERVICES 3.20% 2.30% 0.90% MEDICAL SPECIALTY 12.20% 6.50% 5.70% MEDICAL SUPPLIES 1.90% 1.40% 0.50% PHARMACEUTICALS 6.00% 2.80% 3.20% LIQUID ASSETS 20.30% 0.00% 20.30% ANNUAL MEETING REPORT The Annual Meeting was held on June 25, 2002 at 9:00 a.m. The shareholders voted on the following items and the resulting votes are presented below. (1) To elect two Trustees of the Fund to hold office for a term of three years or until their respective successors shall have been duly elected and qualified. FOR WITHHELD BROKER NON-VOTES --- -------- ---------------- Alan G. Carr 11,312,002 190,275 0 Henri A. Termeer 11,329,924 172,353 0 The nominees were elected to serve until the 2005 Annual Meeting of Shareholders. The Trustees serving until the 2003 Annual Meeting are Lawrence S. Lewin and Uwe E. Reinhardt, Ph.D. The Trustees serving until the 2004 Annual Meeting are Robert P. Mack, M.D., Eric Oddleifson and Oleg M. Pohotsky. (2) To approve a new investment advisory agreement between the Fund and Hambrecht & Quist Capital Management LLC. Shareholders overwhelmingly approved the new investment advisory agreement. FOR AGAINST ABSTAIN BROKER NON-VOTES --- ------- ------- ---------------- 11,241,442 127,177 133,658 0 (3) To ratify the selection of PricewaterhouseCoopers LLP as the Fund's independent accountants for the fiscal year ended September 30, 2002. Shareholders overwhelmingly ratified the selection of the Independent Public Accountants. FOR AGAINST ABSTAIN BROKER NON-VOTES --- ------- ------- ---------------- 11,414,037 32,153 56,087 0 4 REPORT OF INDEPENDENT ACCOUNTANTS TO THE TRUSTEES AND SHAREHOLDERS OF H&Q HEALTHCARE INVESTORS: In our opinion, the accompanying statement of assets and liabilities, including the schedule of investments, and the related statements of operations, of changes in net assets and of cash flows and the financial highlights present fairly, in all material respects, the financial position of H&Q Healthcare Investors (the "Fund") at September 30, 2002, and the results of its operations, the changes in its net assets, its cash flows and the financial highlights for the two years then ended in conformity with accounting principles generally accepted in the United States of America. These financial statements and financial highlights (hereafter referred to as "financial statements") are the responsibility of the Fund's management; our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits of these financial statements in accordance with auditing standards generally accepted in the United States of America, which require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that our audits, which included confirmation of securities at September 30, 2002 by correspondence with the custodian, provide a reasonable basis for our opinion. The financial statements of the Fund as of September 30, 2000 and for the three years then ended were audited by other independent accountants whose report dated November 3, 2000 expressed an unqualified opinion on those statements. PricewaterhouseCoopers LLP Boston, Massachusetts November 19, 2002 5 SCHEDULE OF INVESTMENTS SEPTEMBER 30, 2002 CONVERTIBLE SECURITIES - 29.9% OF NET ASSETS SHARES CONVERTIBLE PREFERRED (RESTRICTED) - 27.9% VALUE ------ ----- AGRICULTURAL/ENVIRONMENTAL TECHNOLOGIES - 1.8% 375,000 Ceres Series C* $2,250,000 27,443 Ceres Series C-1*# 164,658 277,967 Ceres Series D*# 1,667,801 222,222 EPR Series A* 333,333 BIOTECHNOLOGY - 10.8% 400,000 ACADIA Pharmaceuticals Series E* 2,000,000 952,381 Agensys Series C* 3,000,000 2,380,953 Agilix Series B* 3,000,001 850,436 Avalon Pharmaceuticals Series B* 2,999,998 1,818,182 Raven biotechnologies Series B*^ 3,000,000 47,407 Therion Biologics Series A* 177,776 240,000 Therion Biologics Series B*# 900,000 407,712 Therion Biologics Series C*# 1,528,920 36,092 Therion Biologics Sinking Fund* 135,344 1,750,000 Triad Therapeutics Series A* 3,500,000 825,000 Triad Therapeutics Series B* 1,650,000 923,077 Zyomyx Series B* 1,846,153 600,000 Zyomyx Series C* 1,200,000 600,000 Zyomyx Series E* 1,200,000 DIAGNOSTICS - 2.9% 1,371,429 CardioNet Series C*^ 4,800,002 484,829 CytoLogix Series A*^ 400,178 227,130 CytoLogix Series B*#^ 187,472 160,000 Masimo Series D* 1,760,000 HEALTHCARE INFORMATION SERVICES - 1.7% 338,983 KVM Technologies Series B*#^ 3,390 5,384,615 PHT Series D*^ 4,200,000 MEDICAL SPECIALTY - 6.5% 636,364 AbTox Series F*+ 6,364 4,411,764 Concentric Medical Series B* 3,000,000 1,632,653 Omnisonics Medical Technologies Series B*^ 2,400,000 1,034,519 Senomyx Series E* 3,000,002 639,659 Songbird Hearing Series D* 6,397 652,173 TherOx Series H* 2,999,996 820,313 VNUS Medical Technologies Series E*^ 4,200,003 MEDICAL SUPPLIES - 1.4% 343,750 LocalMed Series D* 3,438 631,580 Novacept Series G*# 2,178,951 347,826 Novacept Series H* 1,200,000 PHARMACEUTICALS/DRUG DELIVERY - 2.8% 1,398,732 Galileo Laboratories Series F* 2,999,986 The accompanying notes are an integral part of these financial statements. 6 SHARES CONVERTIBLE SECURITIES - CONTINUED VALUE ------ ----- 211,765 Theravance Series C* $1,905,885 200,000 Theravance Series D-1* 1,800,000 ----------- $67,606,048 ----------- PRINCIPAL AMOUNT CONVERTIBLE BONDS AND NOTES - 2.0% VALUE ------ ----- BIOTECHNOLOGY - 1.8% $6,800,000 CuraGen 6% Cvt. Deb. due 2007ii $4,335,000 DIAGNOSTICS - 0.1% 212,636 CytoLogix (Restricted) 6.75% Cvt. Note, due 2003*^ 212,636 HEALTHCARE INFORMATION SERVICES - 0.0% 1,577,366 FitForAll.com (Restricted) 10% Prom. Note*#+ 158 1,425,982 KVM Technologies (Restricted) Adj.Cvt. Demand Note*#^ 14,260 MEDICAL SPECIALTY - 0.1% 180,000 AbTox (Restricted) 12% Prom. Note*+ 180,000 ----------- $4,742,054 ----------- TOTAL CONVERTIBLE SECURITIES (Cost $87,073,734) $72,348,102 ----------- SHARES COMMON STOCKS - 49.8% ------ AGRICULTURAL/ENVIRONMENTAL TECHNOLOGY - 0.1% 71,483 Catalytica Energy Systems* $248,046 ----------- 248,046 ----------- BIOTECHNOLOGY - 34.0% BIOPHARMACEUTICALS - 27.2% 311,300 Adolor* 4,364,426 429,898 BioTransplant* 748,023 2,760 BioTransplant (Restricted) Warrants (expire 8/12/04)* 0 6,300 BioTransplant (Restricted) Warrants (expire 10/31/04)* 0 1,150 BioTransplant (Restricted) Warrants (expire 8/15/05)* 1,173 410,400 Celgene* 6,911,136 54,000 Cephalon* 2,204,280 441,471 Corixa* 2,794,511 33,164 Corixa Warrants (expire 8/14/07)* 0 550,556 Cubist Pharmaceuticals* 2,813,341 200,001 Cubist Pharmaceuticals (Restricted) Warrants (expire 9/23/03)* 486,202 312,823 CV Therapeutics* 6,541,129 163,000 Genzyme* 3,359,430 426,636 Gilead Sciences* 14,305,105 210,000 MedImmune* 4,393,200 The accompanying notes are an integral part of these financial statements. 7 SHARES BIOTECHNOLOGY - CONTINUED VALUE ------ ----- 226,760 Therion Biologics (Restricted)* $850,350 264,912 Transkaryotic Therapies* 8,585,798 270,270 Tularik* 1,851,350 418,165 Versicor* 3,562,766 18,696 Versicor (Restricted) Warrants (expire 8/3/05)* 56,836 113,700 Vertex Pharmaceuticals* 2,102,313 GENOMICS/DRUG DISCOVERY - 6.8% 297,000 Abgenix* 1,927,530 447,000 deCODE Genetics* 983,400 387,802 Dyax* 752,336 732,600 Exelixis* 3,626,370 111,500 Lexicon Genetics* 447,115 1,191,000 Lynx Therapeutics* 809,880 386,400 Lynx Therapeutics Warrants (expire 4/29/07)* 0 174,461 Molecular Devices* 2,182,507 616,100 Rigel Pharmaceuticals* 985,760 370,237 Telik* 4,583,534 ----------- 82,229,801 ----------- CONTRACT RESEARCH ORGANIZATIONS - 0.4% 91,400 Quintiles Transnational* 869,214 ----------- 869,214 ----------- DIAGNOSTICS - 4.5% 522,617 Biofield* 209,047 600,000 Biofield (Restricted)* 192,000 324,330 Cytyc* 3,476,818 18,500 Digene* 146,150 152,000 IDEXX Laboratories* 4,704,096 160,000 Masimo Labs (Restricted)* 1,600 685,621 Sontra Medical (Restricted)*^ 2,139,138 ----------- 10,868,849 ----------- HEALTHCARE INFORMATION SERVICES - 1.4% 306,208 Syntiro Healthcare Services (Restricted)* 1,200,473 188,096 Syntiro Healthcare Services (Restricted) Warrants* (expire 10/15/04) 18,810 454,500 WebMD* 2,295,225 ----------- 3,514,508 ----------- The accompanying notes are an integral part of these financial statements. 8 SHARES MEDICAL SPECIALTY - 5.7% VALUE ------ ----- 101,848 Biopure Class A* $356,468 8,333 Biopure (Restricted) Warrants (expire 8/4/03)* 0 1,000,000 Endocardial Solutions* 3,230,000 198,000 Endologix* 198,000 441,409 Martek Biosciences* 7,230,279 1,020,000 Orthovita*^ 2,805,000 ------------ 13,819,747 ------------ MEDICAL SUPPLIES - 0.5% 645,000 EP MedSystems* 1,290,000 ------------ 1,290,000 ------------ PHARMACEUTICALS/DRUG DELIVERY - 3.2% 225,000 Aradigm* 472,500 214,800 IVAX* 2,635,596 70,000 Teva Pharmaceutical Industries ADR 4,690,000 ------------ 7,798,096 ------------ TOTAL COMMON STOCKS (Cost $95,051,000) $120,638,261 ------------ PRINCIPAL AMOUNT TEMPORARY CASH INVESTMENTS - 19.7% ------ $11,200,000 American Express Credit, 1.74%, due 10/18/02 $11,190,797 7,000,000 General Electric Capital Corp., 1.75%, due 10/21/02 6,993,194 10,500,000 U.S. Treasury Bill, 1.60%, due 10/17/02 10,492,533 19,000,000 U.S. Treasury Bill, 1.64%, due 10/3/02 18,998,269 ------------ TOTAL TEMPORARY CASH INVESTMENTS (Cost $47,674,793) $47,674,793 ------------ TOTAL INVESTMENTS (Cost $229,799,527) $240,661,156 ============ ------------------- * Non income-producing security. # With warrants attached. ^ Affiliated issuers in which the Fund holds 5% or more of the voting securities (Total Market Value of $24,362,079). ii Security exempt from registration under Rule 144A of the Securities Act of 1933. These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. + Issuer filed for bankruptcy. ADR - American Depository Receipt. The accompanying notes are an integral part of these financial statements. 9 STATEMENT OF ASSETS AND LIABILITIES SEPTEMBER 30, 2002 ASSETS: Investments, at value (identified cost $229,799,527; see Schedule of Investments) $240,661,156 Cash 42,819 Receivable for investments sold 1,673,623 Interest receivable 66,867 Prepaid expenses 29,415 ------------ Total assets $242,473,880 ------------ LIABILITIES: Accrued advisory fee $299,376 Accrued trustees' fees 22,500 Accrued other 146,226 ------------ Total liabilities $468,102 ------------ NET ASSETS $242,005,778 ============ SOURCES OF NET ASSETS: Shares of beneficial interest, par value $.01 per share, unlimited number of shares authorized, amount paid in on 13,323,483 shares issued and outstanding $215,202,502 Accumulated net realized gain on investments 15,941,647 Net unrealized gain on investments 10,861,629 ------------ Total net assets (equivalent to $18.16 per share based on 13,323,483 shares outstanding) $242,005,778 ============ The accompanying notes are an integral part of these financial statements. 10 STATEMENT OF OPERATIONS FOR THE YEAR ENDED SEPTEMBER 30, 2002 INVESTMENT INCOME: Dividend income (net of foreign tax of $4,102) $19,194 Interest income 1,480,403 Other income 2,876 ---------- Total investment income $1,502,473 EXPENSES: Advisory fees $4,233,892 Legal fees 233,494 Trustees' fees and expenses 144,698 Shareholder reporting 126,461 Custodian fees 81,117 Accounting and auditing fees 73,348 Transfer agent fees 53,595 Other 149,092 ---------- Total expenses 5,095,697 ------------ Net investment loss ($3,593,224) ------------ NET REALIZED AND UNREALIZED GAIN (LOSS) ON INVESTMENTS: Net realized gain on investments $33,875,011 Decrease in net unrealized gain on investments (106,220,050) ------------ Net loss on investments ($72,345,039) ------------ Net decrease in net assets resulting from operations ($75,938,263) ============ The accompanying notes are an integral part of these financial statements. 11 STATEMENTS OF CHANGES IN NET ASSETS FOR THE YEAR ENDED SEPTEMBER 30, SEPTEMBER 30, 2002 2001 ------------- ------------- NET INCREASE (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS: Net investment loss ($3,593,224) ($2,222,151) Net realized gain on investments 33,875,011 63,501,379 Decrease in net unrealized gain on investments (106,220,050) (201,564,026) ------------- ------------- Net decrease in net assets resulting from operations ($75,938,263) ($140,284,798) ------------- ------------- DISTRIBUTIONS TO SHAREHOLDERS FROM: Net realized capital gains ($39,468,231) ($52,289,670) ------------- ------------- CAPITAL SHARE TRANSACTIONS: Value of shares issued in reinvestment of distributions (1,281,419 and 1,519,574 shares, respectively) $28,039,066 $36,365,104 ------------- ------------- Net decrease in net assets ($87,367,428) ($156,209,364) NET ASSETS: Beginning of year 329,373,206 485,582,570 ------------- ------------- End of year $242,005,778 $329,373,206 ============= ============= The accompanying notes are an integral part of these financial statements. 12 STATEMENT OF CASH FLOWS FOR THE YEAR ENDED SEPTEMBER 30, 2002 CASH FLOWS USED FOR OPERATING ACTIVITIES: Interest and other income received $1,370,528 Dividends received 19,194 Operating expenses paid (5,158,838) ------------ Net cash used for operating activities ($3,769,116) ------------ CASH FLOWS PROVIDED FROM INVESTING ACTIVITIES Purchases of portfolio securities ($45,375,053) Net sales of temporary cash investments 1,812,048 Sales and maturities of portfolio securities 58,247,860 ------------ Net cash provided from investing activities $14,684,855 ------------ CASH FLOWS USED FOR FINANCING ACTIVITIES: Cash distributions paid, net ($11,429,165) ------------ Net cash used for financing activities ($11,429,165) ------------ NET DECREASE IN CASH ($513,426) CASH AT BEGINNING OF YEAR 556,245 ------------ CASH AT END OF YEAR $42,819 ============ RECONCILIATION OF NET DECREASE IN NET ASSETS RESULTING FROM OPERATIONS TO NET CASH USED FOR OPERATING ACTIVITIES: Net decrease in net assets resulting from operations ($75,938,263) Accretion of discount (112,751) Net realized gain on investments (33,875,011) Decrease in net unrealized gain on investments 106,220,050 Decrease in accrued expenses (50,376) Increase in prepaid expenses (12,765) ------------ Net cash used for operating activities ($3,769,116) ============ Noncash financing activities not included herein consist of stock distributions of $28,039,066. The accompanying notes are an integral part of these financial statements. 13 FINANCIAL HIGHLIGHTS (SELECTED DATA FOR EACH SHARE OF BENEFICIAL INTEREST OUTSTANDING THROUGHOUT THE PERIOD INDICATED) FOR THE YEAR ENDED SEPTEMBER 30, -------------------------------------------------------------------------------- 2002 (1) 2001 2000 1999 1998 ------------ ------------ ------------ ------------ ------------ Net asset value per share: Beginning of year $27.350 $46.147 $21.771 $16.711 $23.106 ------------ ------------ ------------ ------------ ------------ Net investment loss ($0.283)(2) ($0.195)(2) ($0.290) ($0.176) ($0.217) Net realized and unrealized gain (loss) on investments (5.727) (13.822) 28.131 5.596 (5.108) ------------ ------------ ------------ ------------ ------------ Total increase (decrease) from investment operations ($6.010) ($14.017) $27.841 $5.420 ($5.325) ------------ ------------ ------------ ------------ ------------ Capital gains distributions to shareholders ($3.180) ($4.780) ($3.465) ($0.360) ($1.070) ------------ ------------ ------------ ------------ ------------ Net asset value per share: End of year $18.160 $27.350 $46.147 $21.771 $16.711 ============ ============ ============ ============ ============ Per share market value: End of year $14.100 $21.740 $36.188 $16.313 $13.125 Total investment return at market value (25.24%) (27.23%) 151.66% 27.39% (26.05%) RATIOS AND SUPPLEMENTAL DATA: Net assets at end of year $242,005,778 $329,373,206 $485,582,570 $209,519,627 $157,976,073 Ratio of operating expenses to average net assets 1.64% 1.42% 1.45% 1.46% 1.46% Ratio of net investment loss to average net assets (1.16%) (0.62%) (0.86%) (0.91%) (1.11%) Portfolio turnover rate 17.40% 16.17% 12.90% 24.88% 17.15% Number of shares outstanding at end of year 13,323,483 12,042,064 10,522,490 9,623,524 9,453,317 (1) The Fund adopted the provisions of the AICPA Audit and Accounting Guide for Investment Companies and began accreting discounts and amortizing premiums on all debt securities. The effect of this change for the year ended September 30, 2002 was a decrease in net investment loss per share of $.009, an increase in net realized and unrealized loss on investments per share of $.009 and a decrease in the ratio of net investment loss to average net assets from (1.20%) to (1.16%). Per share data and ratios for the periods prior to October 1, 2001 have not been restated to reflect this change in presentation. (2) Net investment loss per share has been computed using average shares outstanding. The accompanying notes are an integral part of these financial statements. 14 NOTES TO FINANCIAL STATEMENTS SEPTEMBER 30, 2002 (1) ORGANIZATION H&Q Healthcare Investors (the Fund) is a Massachusetts business trust registered under the Investment Company Act of 1940 as a diversified closed-end management investment company. The Fund's investment objective is long-term capital appreciation through investment in securities of companies in the healthcare industries. The Fund invests primarily in securities of public and private companies that are believed to have significant potential for above-average growth. The Fund was organized on October 31, 1986 and commenced operations on April 22, 1987. The preparation of these financial statements requires the use of certain estimates by management in determining the entity's assets, liabilities, revenues and expenses. Actual results could differ from these estimates. The following is a summary of significant accounting policies consistently followed by the Fund, which are in conformity with those generally accepted in the United States of America. INVESTMENT SECURITIES Investments traded on national securities exchanges or in the over-the-counter market that are National Market System securities are valued at the last sale price or, lacking any sales, at the mean between the last bid and asked prices. Other over-the-counter securities are valued at the most recent bid prices as obtained from one or more dealers that make markets in the securities. As indicated in Note 4, investments for which market quotations are not readily available are valued at fair value as determined in good faith by the Trustees of the Fund. Temporary cash investments with maturity of 60 days or less are valued at amortized cost. Investment transactions are recorded on a trade date basis. Gains and losses from sales of investments are recorded using the "identified cost" method. Interest income is recorded on the accrual basis. Dividend income is recorded on the ex-dividend date. The Fund adopted the provisions of the AICPA Audit and Accounting Guide for Investment Companies, as revised, effective October 1, 2001 and began accreting discounts and amortizing premiums on all debt securities. Prior to this date, the Fund did not accrete discounts or amortize premiums on long-term debt securities. The cumulative effect of this accounting change had no impact on the total net assets of the Fund, but resulted in an increase in cost of securities and a corresponding decrease in net unrealized appreciation of $154,040 based on securities held as of September 30, 2001. The effect of this change for the fiscal year ended September 30, 2002 was to decrease net investment loss by $112,751 with a corresponding decrease in the change in net unrealized gain on investments of $112,751. FEDERAL INCOME TAXES It is the Fund's policy to comply with the requirements of the Internal Revenue Code applicable to regulated investment companies and to distribute to its shareholders substantially all of its taxable income and its net realized capital gains, if any. Therefore, no Federal income or excise tax provision is required. DISTRIBUTIONS The Fund records all distributions to shareholders from net investment income, if any, and realized gains on the ex-dividend date. Such distributions are determined in conformity with income tax regulations. The Fund has adjusted for the effect of certain permanent book/tax differences by reclassifying the net operating loss against capital, in the amount of $3,439,184, for the year ended September 30, 2002. This adjustment has no effect on the Fund's net 15 assets, net investment loss or net realized gain. The calculation of net investment loss per share in the financial highlights excludes this adjustment. At September 30, 2002, the Fund's undistributed net realized gain on a tax basis was $14,674,239 and differs from accumulated net realized gain on investments due to the timing of recording certain gains. Pursuant to Section 852 of the Internal Revenue Code, the Fund has designated $39,468,231 as a long-term capital gain distribution for its taxable year ended September 30, 2002. DISTRIBUTION POLICY The current distribution policy is to declare distributions in stock. Stock distributions will automatically be paid in newly issued shares of the Fund unless otherwise instructed by the shareholder. Pursuant to an SEC exemptive order, the Fund has implemented a fixed distribution policy that permits the Fund to make quarterly distributions at a rate of 2% of the Fund's net assets to shareholders of record. The Fund intends to use net realized capital gains when making quarterly distributions. This could result in a return of capital to shareholders if the amount of the distribution exceeds the Fund's net investment income and realized capital gains. It is anticipated that net realized capital gains in excess of the total distributed under this policy would be included in the December distribution. STATEMENT OF CASH FLOWS The cash amount shown in the Statement of Cash Flows is the amount included in the Fund's Statement of Assets and Liabilities and represents cash on hand at its custodian and does not include temporary cash investments at September 30, 2002. (2) SECURITIES TRANSACTIONS The aggregate cost of purchases and proceeds from sales of investment securities (other than temporary cash investments) for the year ended September 30, 2002 totaled $44,758,165 and $57,582,430, respectively. At September 30, 2002, the total cost of securities for Federal income tax purposes was $229,799,527. The net unrealized gain on securities held by the Fund was $10,861,629, including gross unrealized gain of $60,162,966 and gross unrealized loss of $49,301,337. (3) INVESTMENT ADVISORY FEES AND OTHER TRANSACTIONS WITH AFFILIATES Effective July 1, 2002, the Fund has entered into an Investment Advisory Agreement (the Advisory Agreement) with Hambrecht & Quist Capital Management LLC (the Adviser). Pursuant to the terms of the Advisory Agreement, the Fund pays the Adviser a monthly fee at the rate when annualized of (i) 2.5% of the average net assets for the month of its venture capital and other restricted securities up to 25% of net assets and (ii) for the month, for all other assets, 1.0% of the average net assets up to $250 million, 0.9% of the average net assets for the next $250 million, 0.8% of the average net assets for the next $500 million and 0.7% of the average net assets thereafter. The aggregate fee may not exceed a rate when annualized of 1.375%. The terms of the agreement prior to July 1, 2002 with the former advisor, Hambrecht & Quist Capital Management Incorporated, an indirect wholly-owned subsidiary of J.P. Morgan Chase & Co., were substantially identical to those in the current Advisory Agreement. Certain officers and Trustees of the Fund are also officers of the Adviser. Trustees who are not affiliates of the Adviser receive an annual fee of $15,000 plus $1,500 for each meeting attended. 16 (4) VENTURE CAPITAL AND OTHER RESTRICTED SECURITIES The Fund may invest in venture capital and other restricted securities if these securities would currently comprise 40% or less of net assets. The value of these securities represents 30% of the Fund's net assets at September 30, 2002. The value of the venture capital and other restricted securities is determined in good faith by the Trustees. However, because of the inherent uncertainty of valuations, these estimated values may differ significantly from the values that would have been used had a ready market for the securities existed, and the differences could be material. In fiscal 2001, the Fund sold a restricted security subject to future contingent payments whose estimated value of $1,647,054 at September 30, 2002 has also been determined by the Trustees and which is included in the Receivable for Investments Sold in the Statement of Assets and Liabilities. The following table details the acquisition date, cost, carrying value per unit, and value of the Fund's venture capital and other restricted securities at September 30, 2002, as determined by the Trustees of the Fund. ACQUISITION CARRYING VALUE SECURITY DATE COST PER UNIT VALUE ------------------------------------ ------------------ ----------- -------------- ---------- AbTox Series F Cvt. Pfd. 3/7/97 $1,461,200 $0.010 $6,364 12% Promissory Note 2/26/98 - 3/26/98 180,000 1.000 180,000 ACADIA Pharmaceuticals Series E Cvt. Pfd. 5/2/00 3,000,594 5.000 2,000,000 Agensys Series C Cvt. Pfd. 2/14/02 3,005,073 3.150 3,000,000 Agilix Series B Cvt. Pfd. 11/8/01 3,014,260 1.260 3,000,001 Avalon Pharmaceuticals Series B Cvt. Pfd. 10/22/01 3,008,325 3.528 2,999,998 Biofield Common 12/15/00 302,984 0.320 192,000 Biopure Common Warrants (expire 8/4/03) 5/13/99 0 0.000 0 BioTransplant Common Warrants (expire 8/12/04) 8/12/94 0 0.000 0 Common Warrants (expire 10/31/04) 10/31/94 0 0.000 0 Common Warrants (expire 8/15/05) 8/18/95 0 1.020 1,173 CardioNet^ Series C Cvt. Pfd. 5/3/01 4,823,823 3.500 4,800,002 Ceres Series C Cvt. Pfd. 12/23/98 1,502,620 6.000 2,250,000 Series C-1 Cvt. Pfd.* 1/4/01 111,488 6.000 164,658 Series D Cvt. Pfd.* 3/14/01 1,668,122 6.000 1,667,801 Concentric Medical Series B Cvt. Pfd. 5/7/02 3,028,055 0.680 3,000,000 Cubist Pharmaceuticals Common Warrants (expire 9/23/03) 9/23/98 235 2.431 486,202 CytoLogix^ Series A Cvt. Pfd. 1/13/98 - 7/21/99 2,332,441 0.825 400,178 Series B Cvt. Pfd.* 1/11/01 1,153,451 0.825 187,472 Cvt. Note 5/29/02 212,636 1.000 212,636 EPR Series A Cvt. Pfd. 3/9/94 1,000,409 1.500 333,333 FitForAll.com 10% Promissory Note* 2/22/00 - 9/18/00 1,613,493 0.010 158 17 ACQUISITION CARRYING VALUE SECURITY DATE COST PER UNIT VALUE ------------------------------------ ------------------ ----------- -------------- ----------- Galileo Laboratories Series F Cvt. Pfd. 8/18/00 $3,002,319 $2.145 $2,999,986 KVM Technologies^ Series B Cvt. Pfd.* 2/19/98 1,501,320 0.010 3,390 Adj. Cvt. Demand Note* 6/21/99 - 6/13/02 1,426,607 0.010 14,260 LocalMed Series D Cvt. Pfd. 2/9/96 1,376,970 0.010 3,438 Masimo Series D Cvt. Pfd. 8/14/96 1,120,040 11.000 1,760,000 Masimo Labs Common 8/14/96 0 0.010 1,600 Novacept Series G Cvt. Pfd.* 3/27/01 3,001,927 3.450 2,178,951 Series H Cvt. Pfd. 4/25/02 1,200,000 3.450 1,200,000 Omnisonics Medical Technologies^ Series B Cvt. Pfd. 5/24/01 2,404,472 1.470 2,400,000 PHT^ Series D Cvt. Pfd. 7/23/01 4,200,000 0.780 4,200,000 Raven biotechnologies^ Series B Cvt. Pfd. 12/12/00 3,000,833 1.650 3,000,000 Senomyx Series E Cvt. Pfd. 2/19/02 3,003,903 2.900 3,000,002 Songbird Hearing Series D Cvt. Pfd. 12/14/00 3,004,861 0.010 6,397 Sontra Medical^ Common 6/24/02 1,679,491 3.120 2,139,138 Syntiro Healthcare Services Common 2/5/97 1,200,325 3.920 1,200,473 Warrants (expire 10/15/04) 10/15/98 0 0.100 18,810 Theravance Series C Cvt. Pfd. 2/5/99 1,800,123 9.000 1,905,885 Series D-1 Cvt. Pfd. 8/28/00 1,800,900 9.000 1,800,000 Therion Biologics Common 7/12/90 - 10/16/96 511,365 3.750 850,350 Series A Cvt. Pfd. 8/20/96 - 10/16/96 444,850 3.750 177,776 Series B Cvt. Pfd.* 2/24/99 - 6/22/99 900,914 3.750 900,000 Series C Cvt. Pfd.* 9/26/01 1,528,922 3.750 1,528,920 Sinking Fund Cvt. Pfd. 10/17/94 - 4/3/96 721,291 3.750 135,344 TherOx Series H Cvt. Pfd. 9/11/00 3,001,873 4.600 2,999,996 Triad Therapeutics Series A Cvt. Pfd. 6/8/99 1,750,860 2.000 3,500,000 Series B Cvt. Pfd. 12/20/00 1,653,135 2.000 1,650,000 Versicor Warrants (expire 8/3/05) 6/28/99 905 3.040 56,836 VNUS Medical Technologies^ Series E Cvt. Pfd. 8/20/01 4,200,003 5.120 4,200,003 Zyomyx Series B Cvt. Pfd. 2/19/99 1,200,550 2.000 1,846,153 Series C Cvt. Pfd. 3/2/00 1,200,690 2.000 1,200,000 Series E Cvt. Pfd. 7/22/02 1,200,000 2.000 1,200,000 ----------- ----------- $84,458,658 $72,959,684 =========== =========== * With warrants attached. ^ Affiliated issuers. 18 TRUSTEES H & Q HEALTHCARE INVESTORS 30 ROWES WHARF, SUITE 430 BOSTON, MASSACHUSETTS 02110 (617) 772-8500 NUMBER OF POSITION(S) HELD WITH PRINCIPAL OCCUPATION(S) PORTFOLIOS IN FUND NAME, ADDRESS(1) FUND, TERM OF OFFICE(2) AND DURING PAST 5 YEARS AND COMPLEX OVERSEEN AND AGE LENGTH OF TIME SERVED OTHER DIRECTORSHIPS HELD BY TRUSTEE ------------------------------------------------------------------------------------------------------------------------------------ INDEPENDENT TRUSTEES: Lawrence S. Lewin Trustee (since 1987) and Executive Consultant. Formerly Chief 2 63 Chairman (since 2000) Executive Officer (from 1970-1999) of The Lewin Group (healthcare public policy and management consulting), a subsidiary of Quintiles Transnational Corp. Robert P. Mack Trustee (since 1991) Consultant in Orthopedic Surgery to 2 67 Orthopedic Associates of Aspen (since 2001). Formerly Orthopedic Surgeon (from 1996-1998) at the Steadman- Hawkins Orthopedic Clinic and (from 1977-1996) at the Denver Orthopedic Clinic; and Director of the Department of Orthopedic Surgery at Metropolitan General Hospital and Assistant Professor of Orthopedics at Case Western Reserve University, Cleveland, OH (from 1968-1977). Eric Oddleifson Trustee (since 1992) Partner (since 2001) and Managing 2 67 Director (from 1997-2000) of Renewable Resources LLC (forest properties investment). Formerly Managing Director (from 1995-1997) of UBS Asset Management (forest properties investment); and President, Director and Chief Investment Officer (from 1984-1995) of Resource Investments, Inc. (forest properties investment). Oleg M. Pohotsky Trustee (since 2000) Most recently, Senior Vice President 2 55 (from 1991-2001) of FAC/Equities, a division of First Albany Corporation (investment bank). Formerly General Partner (from 1989-1991) of Strategic Capital Associates (financial advisory firm); and General Partner (from 1986-1989) of Capital Growth Partners (private mezzanine capital institutional investment partnership). 19 NUMBER OF POSITION(S) HELD WITH PRINCIPAL OCCUPATION(S) PORTFOLIOS IN FUND NAME, ADDRESS(1) FUND, TERM OF OFFICE(2) AND DURING PAST 5 YEARS AND COMPLEX OVERSEEN AND AGE LENGTH OF TIME SERVED OTHER DIRECTORSHIPS HELD BY TRUSTEE ------------------------------------------------------------------------------------------------------------------------------------ INDEPENDENT TRUSTEES: (continued) Uwe E. Reinhardt, Trustee (since 1988) Professor of Economics (since 1968) at 2 Ph.D. Princeton University. Director (from 64 2000) of Triad Hospitals; Boston Scientific (since 2002); Amerigroup since (2002); Duke University (since 2001); The Duke University Health System (since 2001) and the National Bureau of Economic Research (since 2002). Henri A. Termeer Trustee (since 1989) Chairman (since 1988), Chief Executive 2 55 Officer (since 1985) and President (since 1983) of Genzyme Corporation (human healthcare products); Director (since 1987) of ABIOMED, Inc.; Director (since 1992) of AutoImmune, Inc.; Director (from 1993-2002) of Genzyme Transgenics; and Director (since 1996) of Diacrin, Inc. INTERESTED TRUSTEES: Alan G. Carr(3) President Emeritus Chairman (since July 2002) of 2 68 (since 2001), President Hambrecht & Quist Capital Management (from 1987-2001) and LLC; Chairman (from 2001 - July 2002), Trustee (since 1987) President (from 1992-2001), Director (from 1986 to July 2002) and Senior Vice President (from 1986-1992) of Hambrecht & Quist Capital Management, Inc.; and Managing Director (from 1992- 1999) of Hambrecht & Quist Group. (1) The address for each Trustee is c/o the Fund at the Fund's address as set forth above. (2) Each Trustee currently is serving a three year term. (3) Trustee considered to be an "interested person" within the meaning of the Investment Company Act of 1940, as amended (the "1940 Act") through position or affiliation with Hambrecht & Quist Capital Management LLC, the Fund's investment adviser. 20 OFFICERS POSITION(S) HELD WITH NAME, ADDRESS(1) FUND, TERM OF OFFICE(2) AND AND AGE LENGTH OF TIME SERVED PRINCIPAL OCCUPATION(S) DURING PAST 5 YEARS ------------------------------------------------------------------------------------------------------------------------------------ OFFICERS: Alan G. Carr President Emeritus (since 2001) Manager (since July 2002) of Hambrecht & Quist 68 Capital Management LLC; Chairman (from 2001- July 2002), President (from 1992-2001), Director (From 1986 to July 2002) and Senior Vice President (from 1986-1992) of Hambrecht & Quist Capital Management, Inc.; Managing Director (from 1992-1999) of Hambrecht & Quist Group; and President Emeritus (since 2001), President (from 1987-2001) and Trustee (since 1987) of H&Q Healthcare Investors (HQH) and (since 1992) of H&Q Life Sciences Investors (HQL). Daniel R. Omstead, President (since 2001) Manager (since July 2002) of Hambrecht & Quist ENGSCD Capital Management LLC; President of HQH and 49 of HQL (since 2001); President, Chief Executive Officer (from 2001 to July 2002) and Managing Director (from 2000 to July 2002) of Hambrecht & Quist Capital Management Inc.; formerly President and Chief Executive Officer (from 1997-2000) and Chief Operating Officer (1997) of Reprogenesis, Inc. Kimberley L. Carroll Treasurer (since 1987) Treasurer and Chief Financial Officer (since 1987) 46 of HQH and (since 1992) of HQL; and Vice President (from 1991-July 2002) and Treasurer (from 2000 - July 2002) of Hambrecht & Quist Capital Management Inc. Jennifer L. Morris Secretary (since 2001) Secretary (since 2001) of HQH and of HQL; and 34 Assistant Vice President (from 1999-July 2002) and Manager, Corporate Communications (from 1996-1999) of Hambrecht & Quist Capital Management Inc. (1) The address for each officer is c/o the Fund at the Fund's address as set forth above. (2) Each officer serves in such capacity for an indefinite period of time at the pleasure of the Trustees. 21 H&Q HEALTHCARE INVESTORS New York Stock Exchange Symbol: HQH 30 Rowes Wharf, 4th Floor Boston, Massachusetts 02110-3328 www.hqcm.com PLEASE NOTE OUR NEW PHONE NUMBER: (617) 772-8500 OFFICERS Daniel R. Omstead, ENGSCD, President Alan G. Carr, President Emeritus Kimberley L. Carroll, Treasurer Jennifer L. Morris, Secretary TRUSTEES Alan G. Carr Lawrence S. Lewin Robert P. Mack, M.D. Eric Oddleifson Oleg M. Pohotsky Uwe E. Reinhardt, Ph.D. Henri A. Termeer INVESTMENT ADVISER Hambrecht & Quist Capital Management LLC CUSTODIAN AND TRANSFER AGENT State Street Bank and Trust Company INDEPENDENT ACCOUNTANTS PricewaterhouseCoopers LLP LEGAL COUNSEL Dechert Price & Rhoads Shareholders with questions regarding share transfers may call 1-800-426-5523 Interim daily net asset value may be obtained from our website (www.hqcm.com) or by calling 1-800-451-2597 For copies of the Fund's DIVIDEND REINVESTMENT PLAN, please contact the Plan Agent, State Street Bank & Trust Co. P.O. Box 8200, Boston, MA 02266-8200 Telephone: 1-800-426-5523 Out of concern for the environment and in an effort to reduce Fund expenses, this report is printed on recycled paper. HQHCM-AR-02