Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Lamb Peter
   2. Issuer Name and Ticker or Trading Symbol
EXELIXIS, INC. [EXEL] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
EVP, Discovery Research & CSO
(Last)
(First)
(Middle)
C/O EXELIXIS, INC., 210 E. GRAND AVE.		 3. Date of Earliest Transaction (Month/Day/Year)
10/12/2015
(Street)

SOUTH SAN FRANCISCO, CA 94080		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 10/12/2015   M   525 A $ 5.63 36,998 D  
Common Stock 10/12/2015   M   1,400 A $ 5.63 38,398 D  
Common Stock 10/12/2015   M   2,500 A $ 5.63 40,898 D  
Common Stock 10/12/2015   M   8,000 A $ 5.63 48,898 D  
Common Stock 10/12/2015   M   20,000 A $ 5.63 68,898 D  
Common Stock 10/12/2015   M   28,000 A $ 5.63 96,898 D  
Common Stock 10/12/2015   M   84,000 A $ 5.63 180,898 D  
Common Stock 10/12/2015   M   19,333 A $ 5.63 200,231 D  
Common Stock 10/12/2015   M   39,999 A $ 5.63 240,230 D  
Common Stock 10/12/2015   M   39,583 A $ 5.63 279,813 D  
Common Stock 10/12/2015   M   56,936 A $ 5.63 336,749 D  
Common Stock 10/12/2015   S   300,276 D $ 5.839 (1) 36,473 D  
Common Stock 10/13/2015   M   600 A $ 5.63 37,073 D  
Common Stock 10/13/2015   S   600 D $ 5.8 36,473 D  
Common Stock               14,478 I By 401(k) (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Option (right to buy) $ 5.63 10/12/2015   M     525 08/05/2010(3) 10/17/2015 Common Stock 525 $ 0 242,815 D  
Option (right to buy) $ 5.63 10/12/2015   M     1,400 08/05/2010(3) 10/17/2015 Common Stock 1,400 $ 0 241,415 D  
Option (right to buy) $ 5.63 10/12/2015   M     2,500 08/05/2010(3) 10/17/2015 Common Stock 2,500 $ 0 238,915 D  
Option (right to buy) $ 5.63 10/12/2015   M     8,000 08/05/2010(3) 10/17/2015 Common Stock 8,000 $ 0 230,915 D  
Option (right to buy) $ 5.63 10/12/2015   M     20,000 08/05/2010(3) 10/17/2015 Common Stock 20,000 $ 0 210,915 D  
Option (right to buy) $ 5.63 10/12/2015   M     28,000 08/05/2010(3) 10/17/2015 Common Stock 28,000 $ 0 182,915 D  
Option (right to buy) $ 5.63 10/12/2015   M     84,000 08/05/2010(3) 10/17/2015 Common Stock 84,000 $ 0 98,915 D  
Option (right to buy) $ 5.63 10/12/2015   M     19,333 08/05/2010(3) 10/17/2015 Common Stock 19,333 $ 0 79,582 D  
Option (right to buy) $ 5.63 10/12/2015   M     39,999 08/05/2010(3) 10/17/2015 Common Stock 39,999 $ 0 39,583 D  
Option (right to buy) $ 5.63 10/12/2015   M     39,583 08/05/2010(3) 10/17/2015 Common Stock 39,583 $ 0 0 D  
Option (right to buy) $ 5.63 10/12/2015   M     56,936 08/05/2010(4) 10/17/2015 Common Stock 56,936 $ 0 52,149 D  
Option (right to buy) $ 5.63 10/13/2015   M     600 08/05/2010(4) 10/17/2015 Common Stock 600 $ 0 51,549 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Lamb Peter
C/O EXELIXIS, INC.
210 E. GRAND AVE.
SOUTH SAN FRANCISCO, CA 94080		       EVP, Discovery Research & CSO  

Signatures

 /s/ Jeffrey J. Hessekiel, Attorney in Fact   10/13/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.80 to $6.00, inclusive. The reporting person undertakes to provide to Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.
(2) Represents 14,478 shares of Exelixis, Inc. common stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of October 13, 2015.
(3) Option granted pursuant to Issuer's 2000 Equity Incentive Plan. One hundred percent (100%) of the shares vest one year from date of grant.
(4) Option granted pursuant to Issuer's 2000 Equity Incentive Plan. Thirty-three percent (33%) of the shares vest one year from date of grant, and the remaining shares vest in 24 equal monthly installments thereafter.

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